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首页> 外文期刊>Journal of neurology >Age-dependent differences in cervical artery dissection
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Age-dependent differences in cervical artery dissection

机译：颈动脉解剖的年龄依赖性差异

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The goal of this work was to explore agedependent differences in cervical artery dissection (CeAD). This study is based on the Cervical Artery Dissection and Ischemic Stroke Patients population comprising 983 consecutive CeAD patients and 658 control patients with a non-CeAD ischemic stroke (IS), frequency-matched for age and gender. Patients were divided into three age categories: ≤33 (for CeAD, n = 150), 34-54 (n = 688), and ≥55 (n = 145) years, and the youngest and oldest groups were compared. The youngest patients were mostly women and the oldest men. The frequency of internal carotid artery dissection (ICAD) versus vertebral artery dissection (VAD) increased with age from 44 to 75 %. This age-related shift remained significant after adjustment for sex. The frequency of a transient ischemic event as the CeAD symptom declined from 33 % in the youngest age group, to 19 % in the oldest. Vascular risk factors increased in frequency with advancing age in both groups, but for hypertension the increase was steeper for non-CeAD IS patients. For CeAD patients, but not for patients with non-CeAD IS, preceding infection was more common in the oldest group. The youngest non-CeAD IS patients had better functional outcome (modified Rankin Scale 0-1) than the oldest, while the similar trend was not statistically significant among CeAD patients. Younger age seems to be associated with VAD and female gender, and older age with ICAD and male gender. Age-related changes in the frequencies of hypertension and recent infection were different between the CeAD and non-CeAD IS groups. Age does not seem to be an important outcome predictor in CeAD strokes.
机译：这项工作的目的是探讨颈动脉夹层（CeAD）的年龄差异。这项研究基于子宫颈动脉夹层和缺血性卒中患者群体，包括983例连续的CeAD患者和658例非CeAD缺血性卒中（IS）的对照患者，这些患者的年龄和性别相匹配。将患者分为三个年龄段：≤33岁（对于CeAD，n = 150），34-54岁（n = 688）和≥55岁（n = 145）岁，并比较了最年轻和最老的组。最年轻的患者多为女性，而年龄最大的则为男性。随着年龄的增长，颈内动脉解剖（ICAD）与椎动脉解剖（VAD）的频率从44％增加到75％。调整性别后，这种与年龄相关的变化仍然很明显。 CeAD症状引起的短暂性脑缺血事件的频率从最小年龄组的33％下降到最大年龄组的19％。两组中，随着年龄的增长，血管危险因素的频率均增加，但对于非CeAD IS患者，高血压的增加幅度更大。对于CeAD患者，而不是非CeAD IS患者，在最老的组中，先前感染更为常见。最年轻的非CeAD IS患者的功能结局（改良Rankin量表0-1）比最年长的患者好，而在CeAD患者中，相似的趋势在统计学上并不显着。年龄似乎与VAD和女性有关，而年龄较大与ICAD和男性有关。 CeAD组和非CeAD IS组的高血压和近期感染的年龄相关变化是不同的。年龄似乎并不是CeAD中风的重要预后指标。

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