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首页> 外文期刊>Journal of neurology >Hippocampal dysplasia with balloon cells: case report and discussion on classification.
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Hippocampal dysplasia with balloon cells: case report and discussion on classification.

机译：海马不典型增生伴气囊细胞：病例报告及分类讨论。

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Hepatitis E virus (HEV) infection has been identified as a cause of graft hepatitis in liver transplant recipients. The true frequency and clinical importance of HEV infections after liver transplantations is a matter of debate. It is proposed that consumption of HEV-contaminated undercooked meat is a main source for HEV infections in developed countries - which might also account for some hepatitis E cases after organ transplantation. However, HEV is also transmitted by transfusion of blood products, likely representing a previously underestimated risk particularly for patients in the transplant setting. HEV infection can take chronic courses in immunocompromised individuals, associated in some cases with rapid progression to cirrhosis within 1-2years of infection. Diagnosis in transplanted patients is based on HEV RNA testing as antibody assays are not sensitive enough. Selection of immunosuppressive drugs is important as different compounds may influence viral replication and the course of liver disease. Ribavirin has antiviral activity against HEV and should be administered for at least three months in chronically infected individuals; however, treatment failure may occur. HEV infections have also been linked to a variety of extrahepatic manifestations both during and after resolution of infection. In this review we summarize the emerging data on hepatitis E with a particular focus on the importance of HEV infections for liver transplant recipients.
机译：戊型肝炎病毒（HEV）感染已被确定为肝移植受者中移植肝炎的原因。肝移植后HEV感染的真正频率和临床重要性尚有争议。有人建议食用受HEV污染的未煮熟的肉是发达国家HEV感染的主要来源-这也可能解释了器官移植后的一些戊型肝炎病例。然而，戊型肝炎病毒也通过输血传播，可能代表了以前被低估的风险，特别是对于移植患者而言。 HEV感染可在免疫功能低下的个体中接受慢性病程治疗，在某些情况下，在感染后1-2年内会迅速发展为肝硬化。移植患者的诊断基于HEV RNA检测，因为抗体检测不够灵敏。免疫抑制药物的选择很重要，因为不同的化合物可能会影响病毒复制和肝病的进程。利巴韦林具有抗戊型肝炎病毒的抗病毒活性，应在慢性感染的个体中服用至少三个月;但是，可能会发生治疗失败。在感染消退期间和之后，HEV感染也与多种肝外表现有关。在这篇综述中，我们总结了关于戊型肝炎的新兴数据，特别关注戊型肝炎病毒感染对肝移植接受者的重要性。

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