...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of neurology >Effects of non-invasive ventilation on objective sleep and nocturnal respiration in patients with amyotrophic lateral sclerosis
【24h】

Effects of non-invasive ventilation on objective sleep and nocturnal respiration in patients with amyotrophic lateral sclerosis

机译：无创通气对肌萎缩性侧索硬化患者客观睡眠和夜间呼吸的影响

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In amyotrophic lateral sclerosis (ALS), non-invasive ventilation (NIV) is indicated if sleep-disordered breathing (SDB), daytime hypercapnia, or significant diaphragmatic weakness is present. We investigated both short-term and long-term effects of NIV on objective measures of sleep and nocturnal respiration in patients with ALS. Polysomnography (PSG) and transcutaneous capnography were conducted for diagnosis of SDB (T0), for treatment initiation (T1), and follow-up 3, 9, and 15 months later (T2, T3, and T4, respectively). Records from 65 patients were retrospectively analyzed at T0 and T1. At subsequent timepoints, the number of full data sets decreased since follow-up sleep studies frequently included polygraphy rather than PSG (T2, 38 patients, T3, 17 patients, T4, 11 patients). At T0, mean age was 63.2 years, 29 patients were female, and 22 patients had bulbar ALS. Immediate sequelae of NIV initiation included significant increases of slow wave sleep, rapid eye movement sleep, and oxygen saturation. Mean apnea-hypopnea index, respiratory rate, and the maximum transcutaneous carbon dioxide tension were reduced. At T2-T4, normoxia and normocapnia were preserved. Sleep quality measures showed no alteration as diurnal use of NIV gradually increased reflecting disease progression. In contrast to previous reports, improvement of sleep and respiratory outcomes was found in both non-bulbar and bulbar patients. NIV significantly improves objective sleep quality and SDB in the first night of treatment in patients with bulbar and non-bulbar ALS. NIV warrants nocturnal normoventilation without deterioration of sleep quality in the long run with only minor changes to ventilator settings.
机译：在肌萎缩性侧索硬化症（ALS）中，如果存在睡眠呼吸障碍（SDB），白天高碳酸血症或明显的diaphragm肌无力，则应采用无创通气（NIV）。我们调查了NIV对ALS患者睡眠和夜间呼吸的客观测量的短期和长期影响。进行了多导睡眠图（PSG）和经皮二氧化碳描记术以诊断SDB（T0），开始治疗（T1），以及在3、9和15个月后进行随访（分别为T2，T3和T4）。在T0和T1时对65例患者的记录进行回顾性分析。在随后的时间点，完整数据集的数量减少了，因为后续睡眠研究经常包括多面体检查而不是PSG（T2，38例，T3，17例，T4，11例）。在T0，平均年龄为63.2岁，其中29例为女性，22例患有延髓性ALS。 NIV引发的后遗症包括慢波睡眠，快速眼动睡眠和氧饱和度显着增加。平均呼吸暂停低通气指数，呼吸频率和最大经皮二氧化碳张力降低。在T2-T4，常氧和常氧血症得以保留。睡眠质量指标未见变化，因为每日使用NIV逐渐增加，反映出疾病的进展。与以前的报告相反，非灯泡患者和延髓患者均发现睡眠和呼吸结果得到改善。在患有延髓和非延髓ALS的患者中，NIV在治疗的第一夜显着改善了客观睡眠质量和SDB。 NIV保证夜间正常通气，长期而言只需对呼吸机设置进行少量改动就不会降低睡眠质量。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号