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首页> 外文期刊>Journal of neurology >Artistic occupations are associated with a reduced risk of Parkinson's disease
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Artistic occupations are associated with a reduced risk of Parkinson's disease

机译：艺术职业与减少帕金森氏病的风险有关

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Parkinson's disease (PD) is preceded by a premotor phase of unknown duration. Dopaminergic degeneration during this phase may lead to subtle cognitive and behavioural changes, such as decreased novelty seeking. Consequently, premotor subjects might be most comfortable in jobs that do not require optimal dopamine levels, leading to an overrepresentation in structured and predictable occupations, or an underrepresentation in artistic occupations. In a case-control study, 750 men with PD (onset >= 40 years) and 1300 healthy men completed a validated questionnaire about their lifetime occupational status. Occupations were classified using the RIASEC model. Odds ratios (ORs) were calculated for the conventional and artistic categories, both for the most recent occupation before symptom onset, and for the very first occupation. Because farming has been associated with a PD risk, ORs were calculated separately for farming. A reduced risk of PD was found for men with an artistic occupation late in life (OR 0.14, 95 % CI 0.04-0.53), while an artistic first occupation did not prevent PD (OR 0.72, CI 0.32-1.59). Conventional occupations showed no increased risk (recent: OR 1.07, CI 0.70-1.64; first: OR 1.14, CI 0.77-1.71). In support of previous reports, farming was associated with an increased risk of PD (recent: OR 2.6, CI 1.4-4.6; first: OR 2.7, CI 1.6-4.5). PD patients were older than controls, but various statistical corrections for age all lead to similar results. Artistic occupations late in life are associated with a reduced risk of subsequent PD, perhaps because this reflects a better preserved dopaminergic state. No initial occupation predicted PD, suggesting that the premotor phase starts later in life.
机译：帕金森氏病（PD）之前是持续时间未知的运动前期。在此阶段，多巴胺能变性可能导致微妙的认知和行为改变，例如减少寻求新奇事物。因此，运动前的受试者可能在不需要最佳多巴胺水平的工作中最舒适，从而导致结构化和可预测的职业中的代表性过多，或者在艺术性职业中的代表性不足。在一项病例对照研究中，有750名PD患者（发病年龄≥40岁）和1300名健康男性完成了关于其终生职业状况的有效问卷。使用RIASEC模型对职业进行分类。计算常规类别和艺术类别的赔率（OR），包括症状发作之前的最新职业和最开始的职业。由于耕作与PD风险相关，因此针对耕作分别计算OR。对于从事晚年艺术职业的男性，发生PD的风险降低（OR 0.14，95％CI 0.04-0.53），而第一次从事艺术职业不能预防PD（OR 0.72，CI 0.32-1.59）。常规职业没有显示出增加的风险（最近：OR 1.07，CI 0.70-1.64;第一个：OR 1.14，CI 0.77-1.71）。为了支持先前的报告，耕作与PD风险增加相关（最近：OR 2.6，CI 1.4-4.6;首先：OR 2.7，CI 1.6-4.5）。 PD患者年龄大于对照组，但各种年龄的统计学校正均得出相似的结果。晚年的艺术职业与以后发生PD的风险降低有关，也许是因为这反映了更好保存的多巴胺能状态。没有最初的职业预测PD，这表明运动前期开始于生命的后期。

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