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首页> 外文期刊>Biophysical Chemistry: An International Journal Devoted to the Physical Chemistry of Biological Phenomena >A statistical mechanical theory for the adsorption of protein to liposomal membranes
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A statistical mechanical theory for the adsorption of protein to liposomal membranes

机译:蛋白质吸附到脂质体膜的统计力学理论

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The observed topology change of spherical lipid vesicles to coffee cups [Saitoh, A. et al., Proc. Natl. Acad. Sci. USA 95 (1998) 1026] was analyzed by a statistical mechanical theory. The topology change was due to the adsorption of talin molecules to the orifices of the coffee cups. The adsorption isotherm of talin between an aqueous solution and the vesiche membrane was analyzed by taking account of the bending energy of the membrane. The equilibrium is determined by the balance of the energy gain for the adsorption of talin to the periphery of the vesicles and the change of the bending energy of the membrane due to the shape change. The observed coexistence of coffee cups and sheet-like vesicles were reproduced. Vesicles with two orifices were also analyzed and theoretically reproduced.
机译:观察到球形脂质囊泡向咖啡杯的拓扑变化[Saitoh,A. et al。,Proc。 Natl。学院科学[US 95(1998)1026]通过统计力学理论进行了分析。拓扑变化是由于塔林分子吸附到咖啡杯的孔上。考虑到膜的弯曲能,分析了塔林在水溶液和水泡膜之间的吸附等温线。平衡取决于塔林吸附到囊泡周围的能量增益与由于形状变化引起的膜弯曲能的变化之间的平衡。观察到的咖啡杯和片状囊泡共存。还分析了具有两个孔的囊泡,并在理论上进行了复制。

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