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首页> 外文期刊>Clinics in dermatology >Evaluation of a nonsteroidal topical cream in a guinea pig model of Malassezia furfur infection
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Evaluation of a nonsteroidal topical cream in a guinea pig model of Malassezia furfur infection

机译：非甾体外用乳膏在糠Mal马拉色菌糠疹感染豚鼠模型中的评估

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摘要

Malassezia furfur is an important causal factor for seborrheic dermatitis, and topical antifungal therapy is an effective treatment approach. This study assessed the antifungal activity of Promiseb Topical Cream (Promius Pharma, LLC, Bridgewater, NJ), a novel nonsteroidal prescription medical device cream, in the M furfur-infected skin model for guinea pigs. Guinea pigs (N = 28) were divided into 4 groups and infected with M furfur for 7 days. On day 8, the fust group of animals was sacrificed. The scrapings of inoculation site on each animal were tested for the presence of the organism, and the skin was excised for quantitation of M furfur. The second group was left untreated. The remaining 2 groups were treated with one of the test agents (Promiseb) and the positive control product (ciclopirox olamine cream, 0.77%; Loprox, Medicis, Scottsdale, AZ) each once daily for 3 days. At the end of treatment, animals were sacrificed and analyzed similarly to the first group. M furfur was recovered from all animals in the first group. Visual signs of infection, such as erythema and edema, were not observed in the infected animals at the end of the study. In the animals treated for 3 days with the test agents, the M furfur counts were reduced to below the limit of quantitation. Both test agents were equally effective in substantially reducing the density of M furfur compared with the untreated control.
机译：糠Mal马拉色菌是脂溢性皮炎的重要病因，局部抗真菌治疗是一种有效的治疗方法。这项研究评估了Promiseb外用乳膏（Promius Pharma，LLC，Bridgewater，NJ），一种新型的非甾体处方医疗器械乳膏，在感染了糠醛的M型皮肤模型中。将豚鼠（N = 28）分为4组，并用糠fur M感染7天。在第8天，处死几只动物。测试每只动物的接种部位的刮擦物中是否存在该生物，并切下皮肤以定量M糠醛。第二组未经治疗。其余两组分别用一种测试剂（Promiseb）和阳性对照产品（环吡酮醇胺霜，0.77％; Loprox，Medicis，Scottsdale，AZ）每天治疗3天。在治疗结束时，类似于第一组，处死动物并进行分析。从第一组的所有动物中回收了糠fur。在研究结束时，在受感染的动物中未观察到视觉感染迹象，例如红斑和浮肿。在用测试剂处理3天的动物中，糠醛M计数降低到定量限以下。与未处理的对照相比，两种测试剂在实质上降低糠醛M的密度方面均有效。

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