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首页> 外文期刊>Journal of neurology >Papilloedema is an independent prognostic factor for POEMS syndrome
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Papilloedema is an independent prognostic factor for POEMS syndrome

机译：乳头水肿是POEMS综合征的独立预后因素

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摘要

POEMS syndrome is a potentially fatal disease, and prediction of prognostic factors for POEMS syndrome is important for clinicians. Papilloedema is an early sign of the syndrome. The present study was carried out to evaluate whether papilloedema is a prognostic factor for POEMS syndrome. Between January 2003 and December 2012, 94 patients with POEMS syndrome were enrolled in this study. The patients were divided into groups with and without papilloedema. Logistic regression was performed to identify risk factors related to papilloedema. Prognostic factors were analysed with Cox proportional hazard regressions for POEMS syndrome-related prognoses, and survival curves were plotted using the Kaplan-Meier method and compared by the log-rank test. Papilloedema was found in 52.1 % of the patients with POEMS syndrome. Raised intracranial pressure [hazard ratio (HR) 3.06, 95 % confidence interval (CI) 1.24-7.41; P = 0.011] and elevated cerebrospinal fluid protein levels (HR 2.03, 95 % CI 1.07-4.51; P = 0.043) were independently associated with papilloedema. Papilloedema, decreased diffusing capacity of the lung for carbon monoxide (DLCO) and treatment with corticosteroids alone were related to poor prognosis in POEMS syndrome. In multivariate analysis, papilloedema (HR 1.58, 95 % CI 1.05-2.46; p = 0.027) and decreased DLCO (HR 2.17, 95 % CI 1.12-3.39; p — 0.023) were independent factors for POEMS syndrome-related death. Papilloedema and decreased DLCO are important prognostic factors for patients with POEMS syndrome, which can help clinicians predict the risk of mortality and provide better medical care for these patients.
机译：POEMS综合征是一种潜在的致命疾病，因此预测POEMS综合征的预后因素对临床医生很重要。乳头水肿是该综合征的早期征兆。本研究旨在评估乳头水肿是否是POEMS综合征的预后因素。在2003年1月至2012年12月之间，本研究纳入了94名POEMS综合征患者。将患者分为有和没有乳头水肿的组。进行逻辑回归分析以鉴定与乳头水肿相关的危险因素。通过Cox比例风险回归分析对POEMS综合征相关的预后的预后因素，并使用Kaplan-Meier方法绘制生存曲线，并通过对数秩检验进行比较。在POEMS综合征患者中，有52.1％的患者发现了乳头水肿。颅内压升高[危险比（HR）3.06，95％置信区间（CI）1.24-7.41; P = 0.011]和脑脊液蛋白水平升高（HR 2.03，95％CI 1.07-4.51; P = 0.043）与乳头水肿独立相关。乳头水肿，肺对一氧化碳（DLCO）的扩散能力降低以及仅使用皮质类固醇激素治疗与POEMS综合征预后不良有关。在多变量分析中，乳头水肿（HR 1.58，95％CI 1.05-2.46; p = 0.027）和DLCO降低（HR 2.17，95％CI 1.12-3.39; p_0.023）是与POEMS综合征相关的死亡的独立因素。乳头水肿和DLCO降低是POEMS综合征患者的重要预后因素，可帮助临床医生预测死亡风险并为这些患者提供更好的医疗护理。

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