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首页> 外文期刊>Journal of neurology >How predictors and patterns of stroke recurrence after a TIA differ during the first year of follow-up
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How predictors and patterns of stroke recurrence after a TIA differ during the first year of follow-up

机译：在随访的第一年中，TIA后中风复发的预测因素和模式如何不同

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The highest risk of subsequent stroke after a TIA occurs within the first week after the index event. However, the risk of stroke recurrence (SR) remains high during the first year of follow-up. We studied the temporal pattern and predictors of SR (at 7 days and from 7 days to 1-year follow-up). Between April 2008 and December 2009, we included 1,255 consecutive TIA patients from 30 Spanish stroke centers (PROMAPA study). We determined the short-term (at 7 days) and long-term (from 8 days to 1 year) risk of SR. Patients who underwent short-term recurrence and long-term recurrence were compared with regard to clinical findings, vascular territories, and etiology. Enough information (clinical variables and extracranial vascular imaging) was assessed in 1,137 (90.6 %) patients. The 7-day stroke risk was 2.6 %. 32 (3.0 %) patients had an SR after 7-day follow-up. Multiple TIA (HR 3.50, 1.67-7.35, p = 0.001) and large artery atherosclerosis (HR 2.51, 1.17-5.37, p = 0.018) were independent predictors of early SR, whereas previous stroke (HR 1.40, 1.03-1.92, p = 0.034) and coronary heart disease (2.65, 1.28-5.50, p = 0.009) were independent predictors of late SR. Notoriously, 80 % of SR happened in the same territory of the index TIA at 7-day follow-up, whereas only 38 % during the long-term follow-up (p < 0.001). Different predictors of SR were identified throughout the follow-up period. Moreover, the ischemic mechanism differed in early and late stroke recurrences.
机译：TIA后发生中风的最高风险发生在指数事件发生后的第一周内。但是，在随访的第一年中，中风复发的风险仍然很高。我们研究了SR的时间模式和预测因素（在7天和7天至1年的随访中）。在2008年4月至2009年12月之间，我们纳入了来自30个西班牙中风中心的1,255名连续性TIA患者（PROMAPA研究）。我们确定了SR的短期（7天）和长期（8天至1年）风险。比较经历短期复发和长期复发的患者的临床表现，血管区域和病因。在1,137（90.6％）的患者中评估了足够的信息（临床变量和颅外血管成像）。 7天中风的风险为2.6％。 7天的随访后有32名患者（3.0％）发生了SR。多个TIA（HR 3.50，1.67-7.35，p = 0.001）和大动脉粥样硬化（HR 2.51，1.17-5.37，p = 0.018）是早期SR的独立预测因子，而先前卒中（HR 1.40，1.03-1.92，p = 0.034）和冠心病（2.65，1.28-5.50，p = 0.009）是SR晚期的独立预测因子。众所周知，在7天的随访中，有80％的SR发生在TIA指数的同一区域，而在长期随访中，仅有38％的SR发生在该指数中（p <0.001）。在整个随访期间，确定了SR的不同预测因子。此外，缺血性机制在早期和晚期卒中复发中有所不同。

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