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ATTRACTIVE ADSORBATE INTERACTION IN BIOLOGICAL SURFACE REACTIONS

机译:生物表面反应中的吸附性吸附相互作用

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摘要

Recent studies on ferritin adsorption have revealed strong adsorbate interactions during adsorption (H. Nygren, Biophys. J., 65 (1993) 1508). In the present study, efforts were made to quantify the attractive lateral adsorbate interaction and to describe the effect of such interactions on the time- and concentration dependence of biological surface reactions. Attractive forces between ligands increase the time that they are considered neighbours to other ligands. Thus, the inter-ligand interaction effects their distribution and this can be measured experimentally by the pair correlation function g(r). The attractive lateral interaction was shown to affect the surface adsorption of ferritin, virus particles and bacteria, but played a minor role in the binding of antibodies to surface-immobilised antigen. [References: 40]
机译:关于铁蛋白吸附的最新研究已经揭示了在吸附过程中强烈的被吸附物相互作用(H.Nygren,Biophys.J。,65(1993)1508)。在本研究中,已努力量化有吸引力的侧向吸附物相互作用,并描述了这种相互作用对生物表面反应的时间和浓度依赖性的影响。配体之间的吸引力增加了它们被视为与其他配体相邻的时间。因此,配体间相互作用影响它们的分布,这可以通过对相关函数g(r)通过实验测量。已显示出有吸引力的横向相互作用会影响铁蛋白,病毒颗粒和细菌的表面吸附,但在抗体与表面固定抗原的结合中起次要作用。 [参考:40]

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