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首页> 外文期刊>Journal of Neurology, Neurosurgery and Psychiatry >Comparison of the inflammatory burden of truly asymptomatic carotid atheroma with atherosclerotic plaques contralateral to symptomatic carotid stenosis: an ultra small superparamagnetic iron oxide enhanced magnetic resonance study.
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Comparison of the inflammatory burden of truly asymptomatic carotid atheroma with atherosclerotic plaques contralateral to symptomatic carotid stenosis: an ultra small superparamagnetic iron oxide enhanced magnetic resonance study.

机译：真正无症状的颈动脉粥样硬化与有症状的颈动脉狭窄对侧的动脉粥样硬化斑块的炎性负担的比较：超小型超顺磁性氧化铁增强的磁共振研究。

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摘要

BACKGROUND: Inflammation is a recognised risk factor for the vulnerable atherosclerotic plaque. The aim of this study was to explore whether there is a difference in the degree of magnetic resonance (MR) defined inflammation using ultra small superparamagnetic iron oxide (USPIO) particles within carotid atheroma in completely asymptomatic individuals and the asymptomatic carotid stenosis contralateral to the symptomatic side. METHODS: 20 symptomatic patients with contralateral disease and 20 completely asymptomatic patients underwent multi-sequence MR imaging before and 36 h after USPIO infusion. Images were manually segmented into quadrants and signal change in each quadrant was calculated following USPIO administration. Mean signal change was compared across all quadrants in the two groups. RESULTS: The mean percentage of quadrants showing signal loss was 53% in the contralateral group compared with 31% in completely asymptomatic individuals (p = 0.025). The mean percentages showing enhancement were 44% and 65%, respectively (p = 0.024). The mean signal difference between the two groups was 8.6% (95% CI 1.6% to 15.6%; p = 0.017). CONCLUSIONS: Truly asymptomatic plaques seem to demonstrate inflammation but not to the extent of the contralateral asymptomatic stenosis to the symptomatic side. Inflammatory activity may be a significant risk factor in asymptomatic disease.
机译：背景：炎症是易损动脉粥样硬化斑块的公认危险因素。这项研究的目的是探讨在完全无症状的个体和无症状的颈动脉狭窄患者中，使用超小型超顺磁性氧化铁（USPIO）颗粒在颈动脉粥样硬化中定义的炎症程度是否存在差异侧。方法：20例有症状的对侧疾病患者和20例完全无症状的患者在输注USPIO之前和之后36 h进行了多序列MR成像。将图像手动分割为象限，并在USPIO管理后计算每个象限中的信号变化。比较两组中所有象限的平均信号变化。结果：对侧组显示信号丢失的象限平均百分比为53％，而完全无症状的个体为31％（p = 0.025）。显示增强的平均百分比分别为44％和65％（p = 0.024）。两组之间的平均信号差为8.6％（95％CI为1.6％至15.6％; p = 0.017）。结论：真正无症状的斑块似乎显示出炎症，但没有症状侧对侧无症状性狭窄的程度。炎症活动可能是无症状疾病的重要危险因素。

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