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首页> 外文期刊>Journal of orthopaedic research >Elastic fibers of musculoskeletal tissues in bovine Marfan syndrome: a morphometric study.
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Elastic fibers of musculoskeletal tissues in bovine Marfan syndrome: a morphometric study.

机译：牛马凡综合症肌肉骨骼组织的弹性纤维：形态计量学研究。

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摘要

Bovine Marfan syndrome has all the major pathognomonic, clinical, and pathological features of the human syndrome. To further explore the alterations characterizing Marfan syndrome, musculoskeletal tissues from affected and healthy cattle were subjected to histochemical and histomorphometric analysis. Our findings demonstrated reduced elastic fiber content in the periosteum, capsule, interosseous ligament, and flexor tendons of the metatarsophalangeal joint of affected cattle. The elastic properties of a tissue are supplied by elastic fibers in the extracellular matrix; therefore, their reduced content in articular tissues suggests that these fibers could be functionally incompetent to withstand normal stress, causing a predisposition to joint laxity and dislocation. Moreover, perichondrial-periosteal membranes, which are made of collagen and elastic fibers, are known to affect the growth process of the long bones. The decrease in the number of elastic fibers in these membranes could result in reduced restraint of skeletal growth and explain some skeletal abnormalities of Marfan syndrome (i.e., dolichostenomelic habitus).
机译：牛马凡氏综合症具有人类综合症的所有主要病理，临床和病理学特征。为了进一步探讨表征马凡氏综合症的变化，对受影响和健康牛的肌肉骨骼组织进行了组织化学和组织形态分析。我们的研究结果表明，患病牛的pha趾关节的骨膜，囊膜，骨间韧带和屈肌腱中的弹性纤维含量降低。组织的弹性是由细胞外基质中的弹性纤维提供的。因此，它们在关节组织中的含量降低表明，这些纤维在功能上无法承受正常的压力，从而容易导致关节松弛和脱位。此外，已知由胶原蛋白和弹性纤维制成的软骨膜-骨膜膜会影响长骨的生长过程。这些膜中弹性纤维数量的减少可能导致对骨骼生长的抑制降低，并解释了马凡氏综合症的某些骨骼异常（即，多齿寄主性习惯）。

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