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首页> 外文期刊>Journal of orthopaedic research >Silver oxide-containing hydroxyapatite coating has in vivo antibacterial activity in the rat tibia
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Silver oxide-containing hydroxyapatite coating has in vivo antibacterial activity in the rat tibia

机译：含氧化银的羟基磷灰石涂层在大鼠胫骨中具有体内抗菌活性

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摘要

Bacterial infection is a serious postoperative complication of joint replacement. To prevent infections related to implantation, we have developed a novel antibacterial coating with Ag-containing hydroxyapatite (Ag-HA). In the present study, we examined the antibacterial activity of Ag-HA implant coatings in the medullary cavity of rat tibiae. Forty 10-week-old rats received implantation of Ag-HA- or HA-coated titanium rods, then were inoculated with ～1.0 × 102 colony-forming units of methicillin-resistant Staphylococcus aureus. Bacterial counts were calculated for rats euthanized at 24, 48, and 72 h postoperatively. Serum levels of Ag (in the Ag-HA group only) were calculated for rats euthanized at 24, 48, 72 h and 4 weeks. Radiographic evaluations of bone infection were also performed at 4 weeks. Tibiae from both groups showing infection were evaluated histologically. Significant differences in bacterial counts were seen at 24, 48, and 72 h. Mean concentrations of Ag in serum peaked about 48 h after implantation, then gradually decreased. Mean radiographic scores for infection were significantly lower with Ag-HA implants than with HA implants. Histological examination showed better results for abscesses, bone resorption, and destruction of cortical bone around Ag-HA-coated implants. These results indicate that Ag-HA coatings may help prevent surgical-site infections associated with joint replacement.
机译：细菌感染是关节置换术后的严重并发症。为了防止与植入有关的感染，我们开发了一种新型的含银羟基磷灰石（Ag-HA）抗菌涂层。在本研究中，我们检查了Ag-HA植入涂层在大鼠胫骨髓腔中的抗菌活性。 40只10周龄的大鼠接受了Ag-HA或HA涂层的钛棒的植入，然后接种了约1.0×102个耐甲氧西林金黄色葡萄球菌的菌落形成单位。在术后24、48和72小时对安乐死的大鼠进行细菌计数。在24、48、72 h和4周对安乐死的大鼠计算Ag的血清水平（仅在Ag-HA组中）。在第4周还进行了骨感染的影像学评估。对两组显示感染的胫骨进行组织学评估。在24、48和72小时观察到细菌计数的显着差异。血清中Ag的平均浓度在植入后约48小时达到峰值，然后逐渐降低。 Ag-HA植入物的平均放射照相评分明显低于HA植入物。组织学检查显示，在涂有Ag-HA的植入物周围脓肿，骨吸收和皮层骨破坏方面效果更好。这些结果表明，Ag-HA涂层可能有助于预防与关节置换相关的手术部位感染。

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