...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of orthopaedic research >Interleukin-4 and interleukin-13 potentiate interleukin-1 induced secretion of interleukin-6 in human osteoblast-like cells.
【24h】

Interleukin-4 and interleukin-13 potentiate interleukin-1 induced secretion of interleukin-6 in human osteoblast-like cells.

机译：IL-4和IL-13增强了IL-1诱导人成骨样细胞分泌IL-6的能力。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Formation of interleukin-6 (IL-6) in osteoblasts and bone marrow stromal cells is believed to regulate osteoclast recruitment. The anti-inflammatory cytokines interleukin-4 and -13 (IL-4 and IL-13) stimulate IL-6 production in human osteoblasts. We investigated the relative potencies, and synergistic effects, between IL-4, IL-13 and interleukin-1 (IL-1) on IL-6 formation in human osteoblast-like cells. Isolated human osteoblast-like cells were incubated for 72 h in the presence of various concentrations of IL-4, IL-13 and IL-1, and IL-6 secretion was measured by ELISA. All cytokines stimulated the secretion of IL-6. The rank order of potency was IL-1?IL-4>IL-13. There were no additive or synergistic effects between IL-4 and IL-13. However, co-stimulation with IL-1 and IL-4 resulted in a marked synergistic effect on IL-6 secretion. Co- stimulation with IL-1 and IL-13 gave a minor synergistic effect. In conclusion, IL-4/13 synergistically potentiates IL-1 induced secretion of IL-6 in human osteoblast-like cells.
机译：据信成骨细胞和骨髓基质细胞中白介素6（IL-6）的形成调节破骨细胞募集。抗炎细胞因子白细胞介素4和-13（IL-4和IL-13）刺激人成骨细胞中IL-6的产生。我们研究了IL-4，IL-13和白介素-1（IL-1）对人成骨样细胞中IL-6形成的相对效力和协同效应。将分离的人成骨样细胞在各种浓度的IL-4，IL-13和IL-1存在下孵育72小时，并通过ELISA测定IL-6的分泌。所有的细胞因子刺激IL-6的分泌。效价的等级顺序为IL-1≥IL-4＞ IL-13。 IL-4和IL-13之间没有累加或协同作用。但是，与IL-1和IL-4共同刺激导致对IL-6分泌的明显协同作用。与IL-1和IL-13共同刺激产生较小的协同作用。总之，IL-4 / 13协同增强人成骨样细胞中IL-1诱导的IL-6分泌。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号