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首页> 外文期刊>Journal of orthopaedic research >Muscle regeneration and fiber-type transformation during distraction osteogenesis.
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Muscle regeneration and fiber-type transformation during distraction osteogenesis.

机译：牵引成骨过程中的肌肉再生和纤维类型转化。

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The successful outcome of distraction osteogenesis depends in part on the adequate adaptation of the surrounding soft tissue. We characterized the adaptation of the tibialis anterior during distraction osteogenesis at different rates (0.7 and 1.4 mm/day) and amounts (15 and 30%) of lengthening. We documented the increased expression of neonatal and slow myosin heavy chain in the tibialis anterior of skeletally immature rabbits. There was neither expression of neonatal myosin heavy chain in the experimental soleus or in the slow muscle fibers of the tibialis anterior nor increased expression of slow myosin heavy chain in the soleus or gastrocnemius. The increased amount of neonatal myosin heavy chain was concentrated in the distal half of the muscle, whereas the increase in the number of fibers that were labeled with antibodies to slow myosin occurred to the same extent throughout the tibialis anterior. Electrophysiological methods showed that the tibialis anterior was functionally intact during and after distraction osteogenesis. We concluded that in the tibialis anterior of young, skeletally immature animals, distraction osteogenesis seems to induce a recapitulation of the developmental process without leading to functional changes. In addition, during distraction osteogenesis, a fiber-type transformation occurs similar to that observed in models of muscle overloading.
机译：牵引成骨的成功结果部分取决于周围软组织的适当适应性。我们表征了在牵张成骨过程中胫骨前骨的适应性，以不同的速率（0.7和1.4 mm /天）和伸长量（15和30％）进行适应。我们记录了骨骼未成熟兔胫前肌中新生儿和慢肌球蛋白重链的表达增加。实验性比目鱼肌或胫骨前肌的慢肌纤维中均没有新生儿肌球蛋白重链的表达，而在比目鱼肌或腓肠肌中既没有慢肌球蛋白重链的表达增加。新生的肌球蛋白重链增加的数量集中在肌肉的远端，而在整个胫骨前肌中以慢肌球蛋白抗体标记的纤维数量的增加发生的程度相同。电生理方法表明，在牵张成骨过程中和之后，胫前肌在功能上是完整的。我们得出的结论是，在骨骼发育不成熟的年轻胫骨前胫骨中，分心成骨作用似乎会引起发育过程的重现，而不会导致功能改变。另外，在分心成骨过程中，发生类似于肌肉超负荷模型中观察到的纤维类型转化。

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