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首页> 外文期刊>Journal of orthopaedic research >Tendon injury response: assessment of biomechanical properties, tissue morphology and viability following flexor digitorum profundus tendon transection.
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Tendon injury response: assessment of biomechanical properties, tissue morphology and viability following flexor digitorum profundus tendon transection.

机译：肌腱损伤反应：评估指趾屈肌腱腱横断后的生物力学特性，组织形态和生存能力。

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Insertion site injuries of the flexor digitorum profundus (FDP) tendon often present for delayed treatment. Apart from gross observations made at the time of surgery, the changes that occur in the flexor tendon stump during the interval from injury to repair are unknown. These changes may include tendon softening and loss of viability, which may contribute to the poor outcomes observed clinically and experimentally. Thirty-eight FDP tendons from 23 adult dogs were transected sharply from their insertions on the distal phalanges and were not repaired. Dogs were allowed full weight bearing and were euthanized 7 or 21 days after injury. Biomechanical testing indicated that the resistance of injured tendons to pullout of a Kessler-type suture was not different from control tendons at 7 days and was increased at 21 days by 25% ( [Formula: see text] ). Morphologically, at 7 and 21 days the cut surface had a smooth appearance and the end of the injured tendon was increased in thickness by 30% and 50%, respectively ( [Formula: see text] ). Histologically, we observed increased cellularity and dramatic fibroblast proliferation within the injured tendon stump; there was no evidence of decreased cell viability. We conclude that during the interval from 0 to 21 days after FDP insertion-site injury, tendons cells are viable, proliferative and synthesizing new matrix. This leads to increased tendon size and enhanced resistance to suture pullout. These findings offer a scientific rationale supporting the clinical practice of surgical re-attachment within the first 3 weeks after injury.
机译：屈指深屈肌腱（FDP）肌腱的插入部位损伤常表现为延迟治疗。除了在手术时进行的总体观察外，从损伤到修复的间隔中屈肌腱残端中发生的变化是未知的。这些变化可能包括肌腱软化和活力丧失，这可能导致临床和实验观察到的不良预后。从23只成年犬的38条FDP肌腱从其在远端指骨处的插入处进行了尖锐的横断，并且没有得到修复。使狗负重，并在受伤后7或21天对它们实施安乐死。生物力学测试表明，受伤的肌腱对Kessler型缝线的拔出阻力与对照组的肌腱在7天时并无差异，在21天时提高了25％（[公式：参见正文]）。形态上，在第7天和第21天，切面外观光滑，受伤的腱末端厚度分别增加了30％和50％（[公式：参见文本]）。从组织学的角度，我们观察到受伤的肌腱残端内细胞增多，纤维细胞增生迅速。没有证据表明细胞活力降低。我们得出的结论是，在FDP插入部位受伤后0至21天的时间间隔内，肌腱细胞是有活力的，可增殖的并合成新的基质。这导致增加的肌腱尺寸和增强的抗缝合拉力。这些发现提供了科学依据，支持在受伤后的前3周内进行外科手术重新连接的临床实践。

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