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首页> 外文期刊>Journal of orthopaedic research >Kinematics of the ACL-deficient canine knee during gait: serial changes over two years.
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Kinematics of the ACL-deficient canine knee during gait: serial changes over two years.

机译：步态期间ACL缺陷犬膝的运动学：两年内连续变化。

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The ACL-deficient dog is a model for investigating the development and progression of mechanically driven osteoarthrosis of the knee. ACL loss creates dynamic instability in the ACL-deficient knee which presumably leads to progressive joint degeneration, but the nature of this instability over the time course of disease development is not well understood. The goal of this study was to characterize three-dimensional motion of the canine knee during gait, before and serially for two years after ACL transection. Canine tibial-femoral kinematics were assessed during treadmill gait before and serially for two years after ACL transection (ACL-D group; 18 dogs) or sham transection (ACL-I group; five dogs). Kinematic data was collected at 250 frames/s using a biplane video-radiographic system. Six degree-of-freedom motions of the tibia relative to the femur were calculated, and values immediately prior to pawstrike as well as the maximum, minimum, midpoint and range of motion during early/mid stance were extracted. Between-group differences relative to baseline (pre-transection) values, as well as changes over time post-transection, were determined with a repeated-measures ANCOVA. In the ACL-D group, peak anterior tibial translation (ATT) increased by 10 mm ( [Formula: see text] ), and did not change over time ( [Formula: see text] ). Pre-pawstrike ATT was similar to ACL-intact values early on (2-4 months) but then increased significantly over time, by 3.5 mm ( [Formula: see text] ). The range of ab/adduction motion nearly doubled after ACL loss (from 3.3 degrees to 6.1 degrees ). The magnitude (midpoint) of knee adduction also increased significantly over time (mean increase 3.0 degrees; [Formula: see text] ). All changes occurred primarily between 6 and 12 months. There were no significant differences between groups in the transverse plane, and no significant changes over time in the ACL-I group. In summary, peak anterior tibial translation and coronal-plane instability increased immediately after ACL loss,and did not improve with time. ATT just prior to pawstrike and mean knee adduction throughout stance became progressively more abnormal with time, with the greatest changes occurring between 6 and 12 months after ACL transection. This may be due to overload failure of secondary restraints such as the medial meniscus, which has been reported to fail in a similar timeframe in the ACL-deficient dog. The relationships between these complex mechanical alterations and the rate of OA development/progression are currently under investigation.
机译：ACL缺陷狗是用于研究膝关节机械性骨关节炎的发展和进程的模型。 ACL丧失会在ACL不足的膝盖中造成动态不稳定性，这可能导致进行性关节变性，但是这种不稳定性的性质在疾病发展过程中尚不十分清楚。这项研究的目的是表征ACL横断之前和之后连续两年的步态中犬膝的三维运动。在ACL横断（ACL-D组; 18只狗）或假横断（ACL-1组; 5只狗）之前和之后的连续两年的跑步机步态中评估犬胫骨股的运动学。使用双平面视频射线照相系统以250帧/秒的速度收集运动学数据。计算了胫骨相对于股骨的六个自由度运动，并提取了刚进行足击前的值以及早期/中期姿势期间的最大，最小，中点和运动范围。使用重复测量ANCOVA确定相对于基线（横切前）值的组间差异以及横切后随时间的变化。在ACL-D组中，胫骨前平移峰值（ATT）增加了10 mm（[公式：参见文本]），并且没有随时间变化（[公式：参见文本]）。打击前的ATT在早期（2-4个月）与ACL完整值相似，但随着时间的推移明显增加了3.5 mm（[公式：参见文字]）。 ACL丧失后，ab /内收运动的范围几乎翻倍（从3.3度到6.1度）。膝关节内收的幅度（中点）也随时间显着增加（平均增加3.0度; [公式：参见文字]）。所有变化主要发生在6到12个月之间。横断面各组之间无显着差异，ACL-1组随时间变化也无显着变化。综上所述，ACL丧失后，胫骨前平移峰值和冠状面不稳定性立即增加，并没有随时间改善。刚发作前的ATT和随时间变化的平均膝盖内收随着时间逐渐变得更加异常，最大的变化发生在ACL横断后6到12个月之间。这可能是由于次级约束（例如内侧半月板）的过载失败，据报道，该约束在ACL缺陷犬的相似时间范围内失效。这些复杂的机械改变和OA的发展/进展速度之间的关系目前正在研究中。

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