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首页> 外文期刊>Journal of orthopaedic research >Histological and scanning electron microscopy analyses of bone/implant interface using the novel Bonelike synthetic bone graft.
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Histological and scanning electron microscopy analyses of bone/implant interface using the novel Bonelike synthetic bone graft.

机译：使用新型Bonelike合成骨移植物对骨/植入物界面进行组织学和扫描电子显微镜分析。

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摘要

Synthetic bone grafts provide an alternative to autografts and allografts. Bonelike is a patented synthetic bone graft that mimics the mineral composition of bone. The aim of the present work was to assess the biological behavior of Bonelike graft in humans, before using the material in orthopedic applications of bone regeneration, for example, in opening wedge high tibial osteotomies for medial knee osteoarthritis. Bonelike granules were implanted in cortical bone of 11 patients undergoing osteotomies, and new bone formation, osteoconductive properties, and resorption characteristics of the granules were analyzed. The granules ranged from 500 to 1000 microm and were implanted in the lateral aspect of the tibia. The patients' mean age was 59 years (range 48 to 70 years); there were eight women and three men, all suffering from medial compartment osteoarthritis of the knee. At surgery, a 1 x 1 x 1-cm cortical defect was created 3 cm distal to the entry point of the screws, in line with the long axis of tibia. The implanted Bonelike graft sample was extracted for analysis during removal of the metallic prosthesis after implantation times of 6, 9, and 12 months. Radiological follow-up, scanning electron microscopy, histological analysis, and histomorphometric measurements were conducted on the retrieved samples to assess bone regeneration in the defect area. Osteoconductive capacity was demonstrated by extensive mature bone formation around the implanted granules and high levels of percentage bone-to-graft contact (from 67-84%). Bonelike acted as an excellent bioactive scaffold, allowing the migration, proliferation, and differentiation of bone cells on its surface, and therefore regeneration of the defects was achieved in a rapid, controlled manner. Our results suggest that Bonelike graft is an excellent candidate for orthopedic applications where rapid new bone formation is a fundamental requirement.
机译：合成骨移植提供了自体移植和同种异体移植的替代方法。 Bonelike是获得专利的人造骨移植物，可模仿骨骼的矿物质成分。本工作的目的是在将这种材料用于骨再生的整形外科手术之前，例如在为内侧膝关节骨关节炎打开楔形高胫骨截骨术中使用该材料之前，评估人体的骨样移植物的生物学行为。将11例骨质疏松患者的骨皮质植入骨样颗粒，并分析其新骨形成，骨传导特性和吸收特性。颗粒范围为500至1000微米，并植入胫骨的侧面。患者的平均年龄为59岁（范围48至70岁）。有八名女性和三名男性，都患有膝盖内侧腔室骨关节炎。手术时，在距胫骨长轴线的螺钉入口点3 cm远处产生1 x 1 x 1 cm皮质缺损。植入时间分别为6、9和12个月后，取出植入的骨样移植物样品进行金属假体的取出分析。对取回的样品进行放射学随访，扫描电子显微镜，组织学分析和组织形态测量，以评估缺损区域的骨再生。通过植入的颗粒周围大量成熟的骨形成以及高水平的骨与移植物接触百分比（从67％到84％）证明了骨传导能力。骨样起到了极好的生物活性支架的作用，允许骨细胞在其表面上迁移，增殖和分化，因此，缺陷的再生可以快速，可控的方式实现。我们的研究结果表明，骨样移植物是骨科应用的理想候选者，其中快速新骨的形成是基本要求。

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