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首页> 外文期刊>CNS neuroscience & therapeutics >LSD-assisted psychotherapy in persons suffering from anxiety associated with advanced-stage life threatening diseases. A phase-II, double-blind, placebo-controlled dose-response pilot study
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LSD-assisted psychotherapy in persons suffering from anxiety associated with advanced-stage life threatening diseases. A phase-II, double-blind, placebo-controlled dose-response pilot study

机译：在患有与危及生命的晚期疾病相关的焦虑症患者中，LSD辅助的心理治疗。 II期，双盲，安慰剂对照的剂量反应试验研究

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摘要

Lysergic acid diethylamide (LSD) was synthesized in 1938 and its psychoactive effects discovered in 1943. It was used during the 1950s and 1960s as an experimental drug in psychiatric research for producing so-called "experimental psychosis" by altering neurotransmitter system and in psychotherapeutic procedures ("psycholytic" and "psychedelic" therapy). From the mid 1960s, it became an illegal drug of abuse with widespread use that continues today. With the entry of new methods of research and better study oversight, scientific interest in LSD has resumed for brain research and experimental treatments. Due to the lack of any comprehensive review since the 1950s and the widely dispersed experimental literature, the present review focuses on all aspects of the pharmacology and psychopharmacology of LSD. A thorough search of the experimental literature regarding the pharmacology of LSD was performed and the extracted results are given in this review. (Psycho-) pharmacological research on LSD was extensive and produced nearly 10,000 scientific papers. The pharmacology of LSD is complex and its mechanisms of action are still not completely understood. LSD is physiologically well tolerated and psychological reactions can be controlled in a medically supervised setting, but complications may easily result from uncontrolled use by layman. Actually there is new interest in LSD as an experimental tool for elucidating neural mechanisms of (states of) consciousness and there are recently discovered treatment options with LSD in cluster headache and with the terminally ill.
机译：麦角酸二乙酰胺（LSD）于1938年合成，其精神活性于1943年发现。它在1950年代和1960年代用作精神病学研究的实验药物，通过改变神经递质系统和心理治疗程序来产生所谓的“实验性精神病”。 （“精神抑制”和“迷幻”疗法）。从1960年代中期开始，它已成为一种非法滥用药物，广泛使用至今。随着新的研究方法的引入和更好的研究监督，对LSD的科学兴趣已经恢复，用于脑研究和实验治疗。由于自1950年代以来缺乏任何全面的综述，并且缺乏广泛的实验文献，因此本综述着重于LSD药理学和心理药理学的各个方面。对有关LSD药理学的实验文献进行了全面搜索，并在本综述中给出了提取的结果。 LSD的（心理）药理研究广泛，并发表了近10,000篇科学论文。 LSD的药理学很复杂，其作用机理仍不完全清楚。 LSD在生理上具有良好的耐受性，可以在医学监督的情况下控制心理反应，但外行人不加控制地使用可能容易导致并发症。实际上，LSD作为阐明意识（状态）神经机制的实验工具引起了新的兴趣，最近发现了LSD治疗丛集性头痛和绝症的治疗选择。

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