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首页> 外文期刊>Journal of orthopaedic research >Accelerated fracture healing in the geriatric, osteoporotic rat with recombinant human platelet-derived growth factor-BB and an injectable beta-tricalcium phosphate/collagen matrix.
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Accelerated fracture healing in the geriatric, osteoporotic rat with recombinant human platelet-derived growth factor-BB and an injectable beta-tricalcium phosphate/collagen matrix.

机译：重组人血小板源性生长因子-BB和可注射的β-磷酸三钙/胶原蛋白基质可促进老年性骨质疏松大鼠的骨折愈合。

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摘要

Aging and osteoporosis contribute to decreased bone mass and bone mineral density as well as compromised fracture healing rates and bone repair quality. Consequently, the purpose of this study was to determine if recombinant human platelet-derived growth factor-BB (rhPDGF-BB) delivered in an injectable beta-tricalcium phosphate/collagen matrix would enhance tibial fracture healing in geriatric (>2 years of age), osteoporotic rats. A total of 80 rats were divided equally among four groups: Fracture alone; Fracture plus matrix; Fracture plus matrix and either 0.3 mg/mL or 1.0 mg/mL rhPDGF-BB. At 3 and 5 weeks, rats were euthanized and treatment outcome was assessed histologically, radiographically, biomechanically, and by micro-CT. Results indicated rhPDGF-BB-treated fractures in osteoporotic, geriatric rats caused a statistically significant time-dependent increase in torsional strength 5 weeks after treatment. The healed fractures were equivalent in torsional strength to the contralateral, unoperated tibiae. Data from the study are the first, to our knowledge, to underscore rhPDGF-BB efficacy in an injectable beta-tricalcium phosphate/collagen matrix accelerated fracture repair in a geriatric, osteoporotic rat model.
机译：衰老和骨质疏松症导致骨量和骨矿物质密度降低，以及骨折愈合率和骨修复质量下降。因此，本研究的目的是确定在可注射的β-磷酸三钙/胶原蛋白基质中递送的重组人血小板衍生生长因子-BB（rhPDGF-BB）是否可增强老年（> 2岁）胫骨骨折的愈合。 ，骨质疏松大鼠。总共80只大鼠平均分为四组：单独骨折;骨折加基质;骨折加基质以及0.3 mg / mL或1.0 mg / mL rhPDGF-BB。在第3和第5周，对大鼠实施安乐死，并通过组织学，影像学，生物力学和微型CT评估治疗结果。结果表明，rhPDGF-BB治疗的骨质疏松性老年大鼠骨折在治疗后5周引起抗扭强度的统计学显着时间依赖性。愈合的骨折的抗扭强度与对侧未经手术的胫骨相当。据我们所知，这项研究的数据是第一个强调rhPDGF-BB在老年性骨质疏松大鼠模型中可注射的β-磷酸三钙/胶原蛋白基质促进的骨折修复中的功效。

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