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首页> 外文期刊>Journal of orthopaedic research >Changes in conduction, blood flow, histology, and neurological status following acute nerve-stretch injury induced by femoral lengthening.
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Changes in conduction, blood flow, histology, and neurological status following acute nerve-stretch injury induced by femoral lengthening.

机译：股骨延长引起的急性神经舒张损伤后传导，血流，组织学和神经系统状态的变化。

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The effects of an acute stretch on evoked potential, blood flow, histological change, and clinical neurological state were studied in a rat model of acute nerve stretch induced by femoral lengthening. The purposes of this study were to assess, in a model of acute limb lengthening, the safe limits of nerve stretch for nerve function, the pathogenesis of nerve dysfunction, the sensitivity of spinal somatosensory evoked potential, and one of the proposed criteria for irreversible compromise of the sciatic nerve. Thirty-two rats were assigned to one of four groups defined by the degree of acute femoral lengthening (8, 16, 24, and 32%). Spinal somatosensory evoked potential at L5/6 following stimulation of the sciatic nerve was recorded before, immediately after, and 30 minutes after lengthening. Sciatic nerve blood flow was measured by laser Doppler flowmetry at the stretched site before and after lengthening. One week after the operation and without further lengthening, clinical neurological status was evaluated by the functional index of the sciatic nerve and histological examination was performed. At the measurement immediately after the procedure, amplitude changed significantly in all groups except for the group with 8% lengthening. In all groups, sciatic nerve blood flow also dropped significantly compared with values for the control side. Moreover, a greater percentage increase in acute lengthening corresponded with more marked changes in spinal somatosensory evoked potential and sciatic nerve blood flow. The groups that underwent acute lengthening of 24 and 32% had significant neurological deficits and histological changes and demonstrated a significant and profound (50%) drop in amplitude and blood flow. We concluded that spinal somatosensory evoked potential is very sensitive and may serve as an effective tool for the early detection of impending acute nerve-stretch injury and that a 50% reduction in amplitude indicates irreversible damage.
机译：在由股骨延长引起的急性神经伸展的大鼠模型中研究了急性伸展对诱发电位，血流，组织学变化和临床神经系统状态的影响。这项研究的目的是在急性肢体延长模型中评估神经伸展对神经功能的安全极限，神经功能障碍的发病机制，脊柱体感诱发电位的敏感性以及拟议的不可逆折衷标准之一。坐骨神经将三十二只大鼠分为急性股骨延长程度定义的四组之一（分别为8％，16％，24％和32％）。在拉长之前，之后和之后的30分钟，记录坐骨神经受刺激后L5 / 6处的脊髓体感诱发电位。伸长前后，通过激光多普勒血流仪在拉伸部位测量坐骨神经血流量。术后1周且未进一步延长，通过坐骨神经功能指数评估临床神经系统状况，并进行组织学检查。在手术后立即进行测量时，除了延长8％的组外，所有组的幅度均发生了显着变化。在所有组中，与对照侧的值相比，坐骨神经血流量也显着下降。而且，急性延长的百分比增加更大，对应于脊髓体感诱发电位和坐骨神经血流量的更明显变化。接受了24％和32％急性加长的组具有明显的神经功能缺损和组织学改变，并表现出幅度和血流显着而深刻的下降（50％）。我们得出的结论是，脊椎体感诱发电位非常敏感，可以作为早期发现即将发生的急性神经舒张损伤的有效工具，振幅降低50％表示不可逆损伤。

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