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首页> 外文期刊>Journal of orthopaedic research >Compression therapy promotes proliferative repair during rat Achilles tendon immobilization.
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Compression therapy promotes proliferative repair during rat Achilles tendon immobilization.

机译：压缩疗法促进大鼠跟腱固定过程中的增殖修复。

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摘要

Achilles tendon ruptures are treated with an initial period of immobilization, which obstructs the healing process partly by a reduction of blood circulation. Intermittent pneumatic compression (IPC) has been proposed to enhance tendon repair by stimulation of blood flow. We hypothesized that daily IPC treatment can counteract the deficits caused by 2 weeks of immobilization post tendon rupture. Forty-eight Sprague-Dawley SD) rats, all subjected to blunt Achilles tendon transection, were divided in three equal groups. Group A was allowed free cage activity, whereas groups B-C were immobilized at the operated hindleg. Group C received daily IPC treatment. Two weeks postrupture the rats were euthanatized and the tendons analyzed with tensile testing and histological assessments of collagen organization and collagen III-LI occurrence. Immobilization significantly reduced maximum force, energy uptake, stiffness, tendon length, transverse area, stress, organized collagen diameter and collagen III-LI occurrence by respectively 80, 75, 77, 22, 47, 65, 49, and 83% compared to free mobilization. IPC treatment improved maximum force 65%, energy 168%, organized collagen diameter 50%, tendon length 25%, and collagen III-LI occurrence 150% compared to immobilization only. The results confirm that immobilization impairs healing after tendon rupture and furthermore demonstrate that IPC-treatment can enhance proliferative tendon repair by counteracting biomechanical and morphological deficits caused by immobilization.
机译：跟腱断裂在固定初期进行治疗，这部分地通过减少血液循环而阻碍了愈合过程。已经提出了间歇性气动压缩（IPC）以通过刺激血流来增强肌腱修复。我们假设每日的IPC治疗可以抵消肌腱断裂后固定2周引起的缺陷。将48只均接受钝跟腱横断的Sprague-Dawley SD）大鼠分为三组。 A组被允许自由的笼活动，而B-C组被固定在手术后腿。 C组每天接受IPC治疗。破裂后两周，对大鼠实施安乐死，并通过拉伸试验和对胶原组织和III-LI胶原的组织学评估对肌腱进行分析。与游离相比，固定化显着降低了最大力，能量吸收，刚度，肌腱长度，横断面积，应力，组织胶原直径和胶原III-LI发生率，分别降低了80、75、77、22、47、65、49和83％动员。与仅固定相比，IPC治疗可提高最大力量65％，能量168％，组织胶原直径50％，肌腱长度25％和胶原III-LI发生150％。结果证实固定化会削弱腱断裂后的愈合，并且进一步证明IPC治疗可以通过抵消固定化引起的生物力学和形态学缺陷来增强增殖性腱修复。

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