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首页> 外文期刊>Journal of orthopaedic research >Effects of platelet-rich plasma on the quality of repair of mechanically induced core lesions in equine superficial digital flexor tendons: A placebo-controlled experimental study.
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Effects of platelet-rich plasma on the quality of repair of mechanically induced core lesions in equine superficial digital flexor tendons: A placebo-controlled experimental study.

机译：富含血小板的血浆对马浅指屈肌腱机械诱发的核心病变修复质量的影响：一项安慰剂对照实验研究。

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摘要

Tendon injuries are notorious for their slow and functionally inferior healing. Intratendinous application of platelet-rich plasma (PRP) has been reported to stimulate the repair process of tendon injuries, but there is little conclusive evidence for its effectiveness. A placebo-controlled experimental trial was performed to test the hypothesis that a single intratendinous PRP treatment enhances the quality of tendon repair, as evidenced by improved biochemical, biomechanical, and histological tissue properties. In six horses, tendon lesions were created surgically in the Superficial Digital Flexor Tendons (SDFT) of both front limbs, one of which was treated with PRP and the other with saline. After 24 weeks, the tendons were harvested for biochemical, biomechanical, and histological evaluations. Collagen, glycosaminoglycan, and DNA content (cellularity) was higher in PRP-treated tendons (p = 0.039, 0.038, and 0.034, respectively). The repair tissue in the PRP group showed a higher strength at failure (p = 0.021) and Elastic Modulus (p = 0.019). Histologically, PRP-treated tendons featured better organization of the collagen network (p = 0.031) and signs of increased metabolic activity (p = 0.031). It was concluded that PRP increases metabolic activity and seems to advance maturation of repair tissue over nontreated experimentally induced tendon lesions, which suggests that PRP might be beneficial in the treatment of clinical tendon injuries.
机译：肌腱损伤因其缓慢且功能差的愈合而臭名昭著。据报道，在体内应用富血小板血浆（PRP）可刺激肌腱损伤的修复过程，但几乎没有确凿证据证明其有效性。进行了一项安慰剂对照实验试验，以检验以下假设：单一的肌内PRP治疗可增强肌腱修复的质量，这一点已通过改善的生化，生物力学和组织学特性得到证明。在六匹马中，外科手术在两个前肢的浅指屈肌腱（SDFT）中产生了肌腱损伤，其中一只接受PRP治疗，另一只接受生理盐水治疗。 24周后，收获肌腱用于生化，生物力学和组织学评估。在PRP处理过的肌腱中，胶原蛋白，糖胺聚糖和DNA含量（细胞性）更高（分别为p = 0.039、0.038和0.034）。 PRP组的修复组织表现出更高的断裂强度（p = 0.021）和弹性模量（p = 0.019）。组织学上，经PRP处理的肌腱具有更好的胶原网络组织（p = 0.031）和增强的代谢活性迹象（p = 0.031）。结论是，与未治疗的实验性肌腱病变相比，PRP增加了代谢活性，并且似乎促进了修复组织的成熟，这表明PRP在临床肌腱损伤的治疗中可能是有益的。

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