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首页> 外文期刊>Journal of orthopaedic research >Excessive running induces cartilage degeneration in knee joints and alters gait of rats
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Excessive running induces cartilage degeneration in knee joints and alters gait of rats

机译：过度奔跑会导致膝关节软骨变性并改变步态

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The goal of this study was to develop an aggressive running regimen for modeling osteoarthritis (OA) in rats. Twelve Wistar rats were randomly placed into either a running group or a non-running group to serve as the control. The running rats used a motorized treadmill to run either 30 km in 3 weeks or 55 km in 6 weeks. Each week, the prints of hind paws were obtained when rats were made to walk through a tunnel. The resulting prints were digitalized for analyses of stride length and step angle. The histology of the knees was examined at 3 and 6 weeks and the OA pathology in the knees was quantified by Mankin's score. Osteoarthritic pathology developed in the knees of the running rats, including decreased proteoglycan content, uneven type II collagen distribution in the cartilage matrix, increased MMP-13 expression, expanded calcified cartilage zone, and clefts and defects in articular cartilage. The pathology worsened from running for 3 to 6 weeks. Gait analysis revealed an inverse correlation between paw angle and the grades of OA pathology. In conclusion, excessive running induces joint degeneration and a unique gait pattern in rats.
机译：这项研究的目的是开发一种积极的跑步方案来模拟大鼠的骨关节炎（OA）。将十二只Wistar大鼠随机分为跑步组或非跑步组，作为对照组。奔跑的老鼠使用电动跑步机在3周内跑30公里，在6周内跑55公里。每周，当使大鼠穿过隧道时，都会获得后爪的印记。将得到的打印件数字化，以分析步幅和步距角。在第3周和第6周检查膝盖的组织学，并通过Mankin评分量化膝盖的OA病理。奔跑大鼠的膝盖出现骨关节炎病理，包括蛋白聚糖含量降低，软骨基质中II型胶原分布不均，MMP-13表达增加，钙化软骨区扩大以及关节软骨裂隙和缺损。病理从运行3到6周恶化。步态分析揭示了爪角与OA病理分级之间的负相关。总之，过度奔跑会诱发大鼠关节退化和独特的步态模式。

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