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首页> 外文期刊>Journal of orthopaedic research >Effect of atorvastatin on the cortical bones of corticosteroid treated rabbits
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Effect of atorvastatin on the cortical bones of corticosteroid treated rabbits

机译：阿托伐他汀对糖皮质激素治疗兔的皮质骨的影响

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摘要

Osteoporosis ("secondary" osteoporosis) and avascular necrosis (AVN) of the femoral head are well-known adverse effects of corticosteroid therapy. Statins have been reputed to increase bone strength and bone density. In this study, we evaluated the effect of atorvastatin calcium on the flexural properties (3-point bending strength and modulus) of corticosteroid (methylprednisolone acetate) treated rabbit femurs and tibias. Our study hypothesis was that the use of statins would counteract the loss of bone strength caused by corticosteroid treatment. The 40 rabbits were divided into 5 groups: control, corticosteroid alone and corticosteroid combined with oral doses of atorvastatin calcium (2, 10, or 20 mg/day). A daily oral dose of atorvastatin calcium treatment for 70 days weakened the long bones of methylprednisolone acetate treated rabbits irrespective of the dosage (2, 10, or 20 mg). Cortical bone strength was assessed using the 3-point bending test at the end of the study period. A daily oral dose of atorvastatin calcium did not attenuate the loss of cortical bone strength caused by corticosteroid treatment in rabbits. It appeared to decrease that bone strength. If these results hold true in humans, they would have wide applicability given the frequent combined use of corticosteroids and statins in many patients.
机译：骨质疏松症（“继发性”骨质疏松症）和股骨头缺血性坏死（AVN）是皮质类固醇治疗的众所周知的不良反应。他汀类药物可以增加骨骼强度和骨密度。在这项研究中，我们评估了阿托伐他汀钙对皮质类固醇（醋酸甲泼尼龙）治疗的股骨和胫骨的弯曲特性（3点弯曲强度和模量）的影响。我们的研究假设是，他汀类药物的使用将抵消由皮质类固醇治疗引起的骨强度损失。 40只兔子分为5组：对照组，单独使用皮质类固醇和皮质类固醇联合口服阿托伐他汀钙（2、10或20 mg /天）。每天口服阿托伐他汀钙治疗70天，无论剂量（2、10或20 mg）如何，都会削弱醋酸甲泼尼龙治疗的兔子的长骨。在研究期结束时，使用3点弯曲测试评估了皮质骨强度。每天口服阿托伐他汀钙并不能减轻家兔皮质类固醇激素治疗引起的皮质骨强度损失。它似乎降低了骨骼强度。如果这些结果在人类中成立，考虑到许多患者经常联合使用皮质类固醇和他汀类药物，它们将具有广泛的适用性。

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