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首页> 外文期刊>Journal of orthopaedic research >Entropy analysis of tri-axial leg acceleration signal waveforms for measurement of decrease of physiological variability in human gait
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Entropy analysis of tri-axial leg acceleration signal waveforms for measurement of decrease of physiological variability in human gait

机译：三轴腿部加速度信号波形的熵分析，用于测量人体步态的生理变异性降低

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摘要

Disease-related and senescent decrease of physiological variability in biological time-series outputs (e.g., heart rate) has drawn increasing attention as a potential new type of biomarker. In this paradigm, measurement of variability in periodic motion may enable quantitative evaluation of functional limitation in people with musculoskeletal disorders. A novel technique to measure variability of leg motion patterns during level walking was used to study 52 adults with symptomatic knee osteoarthritis (OA), and 57 asymptomatic control subjects over a wide range of age (20-79 years). The hypothesis was that cycle-to-cycle variability in leg motion patterns, indexed by tri-axial acceleration signal entropy, would be lower in those with greater age or with knee symptoms. Leg motions were assessed using portable inertial monitors attached bilaterally just above each ankle. The tri-axial acceleration data were analyzed using a nonlinear variability measurement tool designated as Sample Entropy (SampEn). SampEn data for asymptomatic subjects exhibited a significant negative correlation (r = -0.287, p = 0.0306) with greater age. OA subjects had significantly lower SampEn values (p = 0.0002) than did age-matched asymptomatic subjects who walked at equivalent velocity. This approach holds promise as a basis for valid, inexpensive, and convenient objective evaluation of limitations in human gait function.
机译：与疾病相关的衰老和生物衰老在生物时间序列输出（例如心率）中的生理变异性降低已引起人们越来越多的关注，作为一种潜在的新型生物标志物。在这种范例中，测量周期性运动的变异性可以定量评估肌肉骨骼疾病患者的功能受限。一种用于测量水平步行过程中腿部动作模式变化的新技术用于研究52位有症状的膝关节骨关节炎（OA）的成年人和57位无症状对照受试者，其年龄范围广泛（20-79岁）。假设是，年龄较大或有膝部症状的患者，腿部运动模式的周期变化（以三轴加速度信号熵为指标）将较低。使用便携式惯性监测器评估双腿的运动，该监测器在两侧分别位于每个脚踝上方。使用称为样本熵（SampEn）的非线性变异性测量工具分析了三轴加速度数据。无症状受试者的SampEn数据随着年龄的增长呈显着负相关（r = -0.287，p = 0.0306）。与以同等速度行走的年龄匹配的无症状受试者相比，OA受试者的SampEn值显着更低（p = 0.0002）。这种方法有望成为对人的步态功能限制进行有效，廉价和方便的客观评估的基础。

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