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首页> 外文期刊>Clinics in dermatology >The multifunctional role of ectoine as a natural cell protectant.
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The multifunctional role of ectoine as a natural cell protectant.

机译：果胶作为天然细胞保护剂的多功能作用。

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摘要

The protective properties of ectoine, formerly described for only extremophilic microorganisms, can be transferred to human skin. Our present data show that the compatible solute ectoine protects the cellular membrane from damage caused by surfactants. Transepidermal water loss measurements in vivo suggest that the barrier function of the skin is strengthened after the topical application of an oil in water emulsion containing ectoine. Ectoine functions as a superior moisturizer with long-term efficacy. These findings indicating that ectoine is a strong water structure-forming solute are explained in silico by means of molecular dynamic simulations. Spherical clusters containing (1) water, (2) water with ectoine, and (3) water with glycerol are created as model systems. The stronger the water-binding activity of the solute, the greater the quantity of water molecules remaining in the cluster at high temperatures. Water clusters around ectoine molecules remain stable for a long period of time, whereas mixtures of water and glycerol break down and water molecules diffuse out of the spheres. On the basis of these findings, we suggest that the hydrogen bond properties of solutes are not solely responsible for maintaining the water structure form. Moreover, the particular electrostatic potential of ectoine as an amphoteric molecule with zwitterionic character is the major cause for its strong affinity to water. Because of its outstanding water-binding activity, ectoine might be especially useful in preventing water loss in dry atopic skin and in recovering skin viability and preventing skin aging.
机译：以前只描述过极端微生物的果胶的保护特性可以转移到人的皮肤上。我们目前的数据表明，相容的溶质水合碱可保护细胞膜免受表面活性剂造成的损害。体内经表皮失水量的测量表明，局部应用含有ectoine的水包油乳剂后，皮肤的屏障功能得到了增强。 Ectoine具有出色的保湿效果，并具有长期疗效。通过分子动力学模拟，在计算机模拟中解释了这些表明果胶是形成水结构的强溶质的发现。创建了包含（1）水，（2）带有水合水和（3）带有甘油的水的球团作为模型系统。溶质的水结合活性越强，高温下簇中残留的水分子数量就越大。外在分子周围的水团簇在很长一段时间内保持稳定，而水和甘油的混合物分解，水分子扩散出球体。根据这些发现，我们建议溶质的氢键性质不仅仅负责维持水的结构形式。此外，作为具有两性离子特性的两性分子，油桃素的特定静电势是其与水的强亲和力的主要原因。由于其杰出的水结合活性，ectoine在防止干燥异位性皮肤水分流失，恢复皮肤活力和防止皮肤衰老方面尤其有用。

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