...
首页> 外文期刊>Clinics in dermatology >Hyaluronan in skin: aspects of aging and its pharmacologic modulation.
【24h】

Hyaluronan in skin: aspects of aging and its pharmacologic modulation.

机译:皮肤中的透明质酸:衰老及其药理学调节方面。

获取原文
获取原文并翻译 | 示例
           

摘要

Hyaluronan is a glycosaminoglycan polymer prominent in embryogenesis and in tissues undergoing repair. It is responsible for the water content of skin, where half the hyaluronan of the body is present. As in other tissues, it undergoes rapid turnover. Its biology is vastly different between dermis and epidermis. Levels do not diminish with age but instead become increasingly associated with tissues and resistant to extraction in vitro. Hyaluronan-binding proteins are involved, most of which remain unidentified. Hyaluronan size is critical for its various functions. High molecular size reflects intact tissues and antiangiogenic and immunosuppressive state, whereas smaller polymers are distress signals and potent inducers of inflammation and angiogenesis.
机译:透明质酸是一种糖胺聚糖聚合物,在胚胎发生和接受修复的组织中突出。它负责皮肤的水分含量,而人体透明质酸的含量则占一半。与其他组织一样,它经历了快速周转。真皮和表皮的生物学差异很大。水平不会随着年龄的增长而降低,而是与组织越来越相关,并且对体外提取具有抵抗力。涉及乙酰透明质酸结合蛋白,其中大多数仍未被鉴定。透明质酸的大小对其各种功能至关重要。高分子大小反映了完整的组织以及抗血管生成和免疫抑制状态,而较小的聚合物则是窘迫信号,是炎症和血管生成的有效诱因。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号