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首页> 外文期刊>Journal of orthopaedics and traumatology: official journal of the Italian Society of Orthopaedics and Traumatology >Effects of alendronate medication on the fate of the necrotic femoral head of rats with or without core decompression
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Effects of alendronate medication on the fate of the necrotic femoral head of rats with or without core decompression

机译：阿仑膦酸药物对有无核心减压的大鼠股骨头坏死的影响

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摘要

After producing bilateral osteonecrosis of the femoral head, rats were medicated alendronate according to one of 6 schedules, In group 1 injection was administered one week prior to the operation of devascularization and thereafter was continued for another 42 days. In group 2, medication started on the day of the operation The control group 3 was similarly handled except that they were given injections of physiological saline Group.4 animals were subjected to drilling of the right femoral head and treated with alendronate a week before the operation and 42 days thereafter, while in group 5 medication begun on the day of the operation. Control group 6 was similarly handled, but received physiological saline The furthest advanced changes occurred in groups 3 and 6 (in which an advanced stage of an osteoarthritis-like disorder were observed) followed by groups 4 and 5 (in which alterations were mild to moderate), and finally by groups 1 and 2 (in which there were but mild changes). In addition, all changes were less pronounced in the animals which had been treated with alendronate for one week prior to the operation than in those given the first dose from the operative day. These findings demonstrate that bisphosphonate medication preserves the shape of rats' femoral heads in the early post-necrotic phase to a greater degree than in the Authors' earlier, diverse attempts to arrest the disastrous progression of the post-necrotic remodeling towards hip osteoarthri-tis. The presented findings warrant the preclinical trial of bisphosphonate therapy in patients admitted for the management of osteonecrosis of the femoral head.
机译：在产生股骨头的双侧骨坏死之后，按照6种方案之一给大鼠服用阿仑膦酸盐。在第1组中，在进行血运重建之前一周注射一次，然后继续进行42天。在第2组中，在手术当天开始用药。对对照组3进行相同的处理，只是给他们注射生理盐水。第4组动物在手术前一周进行右股骨头钻孔并用阿仑膦酸盐治疗之后的42天，而在第5组中，手术当天开始用药。对照组6的处理类似，但接受生理盐水。3和6组（观察到骨关节炎样疾病的晚期）发生了最远的晚期改变，随后是4和5组（轻度至中度改变） ），最后按第1组和第2组（但变化不大）进行。另外，在手术前一个星期用阿仑膦酸盐治疗的动物中，所有变化均不如从手术当天开始给予第一剂的动物明显。这些发现表明，双膦酸盐药物在坏死后早期可以更大程度地保护大鼠股骨头的形状，这比作者在早期进行的多种尝试来阻止坏死后重塑向髋骨关节炎的灾难性进展。 。提出的发现需要对接受双膦酸盐治疗的股骨头骨坏死患者进行临床前试验。

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