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首页> 外文期刊>Journal of orthopaedics and traumatology: official journal of the Italian Society of Orthopaedics and Traumatology >How do porosity-inducing techniques affect antibiotic elution from bone cement? An in vitro comparison between hydrogen peroxide and a mechanical mixer
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How do porosity-inducing techniques affect antibiotic elution from bone cement? An in vitro comparison between hydrogen peroxide and a mechanical mixer

机译：孔隙诱导技术如何影响骨水泥中的抗生素洗脱？过氧化氢和机械混合器的体外比较

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Increasing the porosity of an antibiotic-loaded cement spacer increases the antibiotic elution, but the correlation between porosity and antibiotic elution is not well documented. The purposes of this study was to attempt new porosity-increasing methods and to investigate the correlation between antibiotic elution and both total and surface porosity. Materials and methods Five types of antibiotic-loaded bone cement (ALBC) using 2 g cefazolin and 40 g cement were prepared. Other than manual mixing, hydrogen peroxide was used as a foaming agent and a mixing drill piece was used as a mechanical device to try to induce porosity when mixing the cement. Elution of antibiotic into phosphate-buffered saline was measured from 1 h to 1 week. Surface porosity was calculated from density values which were measured with a density kit and an electronic balance, while total porosity was quantified using micro-computed tomography.
机译：增加装有抗生素的水泥垫片的孔隙度会增加抗生素的洗脱，但是孔隙度和抗生素洗脱之间的相关性尚未得到充分证明。这项研究的目的是尝试增加孔隙率的新方法，并研究抗生素洗脱与总孔隙率和表面孔隙率之间的相关性。材料和方法制备了5种类型的使用2 g头孢唑啉和40 g水泥的抗生素骨水泥（ALBC）。除了手动搅拌以外，还使用过氧化氢作为发泡剂，并使用混合钻头作为机械设备，以试图在混合水泥时引起孔隙。从1小时到1周测量抗生素在磷酸盐缓冲液中的洗脱。由使用密度套件和电子天平测量的密度值计算表面孔隙率，而使用微计算机断层摄影术对总孔隙率进行定量。

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