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首页> 外文期刊>Journal of pediatric endocrinology & metabolism: JPEM >Octreotide-induced hepatitis in a child with persistent hyperinsulinemia hypoglycemia of infancy
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Octreotide-induced hepatitis in a child with persistent hyperinsulinemia hypoglycemia of infancy

机译：奥曲肽诱导的儿童持续性高胰岛素血症婴儿期低血糖的肝炎

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摘要

Persistent hyperinsulinemic hypoglycemia of infancy (PHHI), the most common cause of persistent hypoglycemia in the neonatal period and infancy, is a genetic disorder characterized by abnormal regulation of insulin secretion. Octreotide, a somatostatin analog, is often used as a second-line treatment when diazoxide therapy fails to control hypoglycemia. We report herein a rare development of octreo-tide-induced hepatitis following prolonged treatment for PHHI in an infant. Octreotide-induced hepatitis may occur mostly when high doses are given, or when dosing is increased. This warrants routine examination of liver function. When hepatitis develops, prompt cessation of octreo-tide therapy will probably result in subsequent resolution.
机译：婴儿持续性高胰岛素血症性低血糖症（PHHI）是新生儿期和婴儿期持续性低血糖症最常见的原因，是一种以胰岛素分泌异常调节为特征的遗传性疾病。当二氮嗪治疗无法控制低血糖时，生长抑素类似物奥曲肽常被用作二线治疗。我们在这里报告了婴儿PHHI的长期治疗后，由奥曲肽诱发的肝炎的罕见发展。当给予高剂量或增加剂量时，奥曲肽诱发的肝炎通常会发生。这需要常规检查肝功能。当肝炎发作时，立即停止使用奥曲肽治疗可能会导致随后的消退。

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