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首页> 外文期刊>Journal of pediatric gastroenterology and nutrition >Natural history of paediatric inflammatory bowel diseases over a 5-year follow-up: a retrospective review of data from the register of paediatric inflammatory bowel diseases.
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Natural history of paediatric inflammatory bowel diseases over a 5-year follow-up: a retrospective review of data from the register of paediatric inflammatory bowel diseases.

机译：小儿炎症性肠病的自然病史超过5年的随访：对小儿炎症性肠病登记簿中数据的回顾性回顾。

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OBJECTIVES: The natural history of paediatric inflammatory bowel diseases (IBDs) is poorly understood. We aim to describe the disease course in this cohort and generate prognostic information for patients and clinicians. MATERIALS AND METHODS: Patient records from 6 tertiary paediatric gastroenterology centres were reviewed to generate data concerning original diagnosis, change in diagnosis, family history, surgical interventions, growth, and presence of extragastrointestinal manifestations. RESULTS: Data were collected on 116 children with Crohn disease (CD), 74 with ulcerative colitis (UC), and 20 with indeterminate colitis (IC), followed for a mean period of 3.42, 3.3, and 2.9 years from date of diagnosis, respectively. A male predominance is demonstrated in CD. Revision of diagnosis in patients with IC is mainly to UC, with most children receiving a definitive diagnosis within 2 years of initial presentation. Of the children with UC, 17.6% underwent 1 or more major operations with a median time to surgery of 1.92 years. Of children with CD, 11.6% underwent 1 or more major intraabdominal procedures with a median time to surgery of 1.83 years. We recorded a positive family history in 2.7%, 8.2%, and 10% of cases for CD, UC, and IC, respectively. For both boys and girls with CD, but only for boys with UC, height standard deviation score became more negative over time. CONCLUSIONS: This retrospective study quantifies certain distinctions between IBDs diagnosed in paediatric and adult populations. We document a trend toward male predominance in children with CD. We also note impaired linear growth in children with CD, whereas it appears maintained in girls with UC. We also have recorded a low incidence of IBDs in the families of this cohort and suggest that environmental influences may be of greater importance. We document that major intraabdominal surgery may be required in about 15% of patients with either UC or CD within 2 years of diagnosis, and that the majority of those diagnosed initially with IC will be reclassified as either UC or CD within 2 years.
机译：目的：对小儿炎症性肠病（IBDs）的自然病程了解甚少。我们旨在描述此队列中的疾病过程，并为患者和临床医生提供预后信息。材料与方法：审查了来自6个三级小儿肠胃病学中心的患者记录，以产生有关原始诊断，诊断改变，家族史，外科手术，生长以及胃肠外表现的数据。结果：收集了116例克罗恩病（CD），74例溃疡性结肠炎（UC）和20例不确定性结肠炎（IC）儿童的数据，其平均诊断时间为3.42、3.3和2.9年，分别。 CD中显示出男性占主导地位。对IC患者的诊断修改主要是针对UC，大多数儿童在初次就诊后的两年内接受了明确的诊断。在患有UC的儿童中，有17.6％进行了1次或更多次大手术，平均手术时间为1.92年。在患有CD的儿童中，有11.6％接受了1次或多次大腹腔手术，中位手术时间为1.83年。我们在CD，UC和IC的病例中分别记录了2.7％，8.2％和10％的阳性家族史。对于患有CD的男孩和女孩，但仅对于患有UC的男孩，身高标准差得分随着时间的推移变得越来越负。结论：这项回顾性研究量化了在儿科和成人人群中诊断出的IBD之间的某些区别。我们记录了CD患儿中男性占主导地位的趋势。我们还注意到，患有CD的儿童的线性生长受损，而患有UC的女孩似乎保持了这种生长。我们还记录了该人群家庭中IBD的发生率较低，并表明环境影响可能更为重要。我们记录到，在诊断后2年内，约有15％的UC或CD患者可能需要进行大腹腔手术，并且最初诊断为IC的大多数患者将在2年内重新分类为UC或CD。

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