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首页> 外文期刊>Journal of pediatric hematology/oncology: Official journal of the American Society of Pediatric Hematology/Oncology >Prevalence and Predictors of Overweight and Obesity Among a Multiethnic Population of Pediatric Acute Lymphoblastic Leukemia Survivors: A Cross-Sectional Assessment
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Prevalence and Predictors of Overweight and Obesity Among a Multiethnic Population of Pediatric Acute Lymphoblastic Leukemia Survivors: A Cross-Sectional Assessment

机译：小儿急性淋巴细胞白血病幸存者多族裔人群中超重和肥胖的患病率和预测因素：跨领域评估

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摘要

As previous studies of obesity in survivors of pediatric acute lymphoblastic leukemia (ALL) have primarily been conducted among non-Hispanic white survivors or children treated on older protocols, our objective was to describe the prevalence and correlates of overweight status among an ethnically diverse population of pediatric ALL survivors, largely treated with more contemporary therapies. We evaluated the overweight/obesity status of pediatric ALL survivors (n=406) followed in the Texas Children's Cancer Center between 2004 and 2014. Survivors were classified as underweight, normal weight, overweight, or obese on the basis of their body mass index at their most current follow-up visit. Our results showed that Hispanic ethnicity (39% of the subjects) was associated with being overweight (adjusted odds ratio=1.88; 95% confidence interval, 1.13-3.14) or obese (adjusted odds ratio=2.84; 95% confidence interval, 1.59-5.06) at follow-up, even after adjusting for cranial radiotherapy (CRT) exposure. Body mass index z-score at diagnosis was also associated with overweight/obesity at follow-up. In addition, there was a statistically significant interaction between younger age at diagnosis and CRT, indicating that younger age at diagnosis was associated with obesity among patients who received CRT. These findings may help identify pediatric ALL patients that are at increased risk of being overweight or obese after treatment.
机译：由于先前在小儿急性淋巴细胞性白血病（ALL）幸存者中进行的肥胖症研究主要是在非西班牙裔白人幸存者或接受较老方案治疗的儿童中进行的，因此我们的目标是描述在不同种族的人中超重状态的患病率和相关性儿科所有幸存者，大部分接受了更多当代疗法的治疗。我们评估了2004年至2014年在德克萨斯州儿童癌症中心接受随访的儿科ALL幸存者（n = 406）的超重/肥胖状况。根据其体重指数，将幸存者分为体重过轻，正常体重，超重或肥胖他们最近的随访。我们的结果表明，西班牙裔（占受试者的39％）与超重（调整后的优势比= 1.88; 95％的置信区间为1.13-3.14）或肥胖（调整后的优势比= 2.84; 95％的置信区间为1.59- 5.06），即使调整了颅骨放疗（CRT）暴露量也是如此。诊断时的体重指数z分数也与随访时的超重/肥胖有关。此外，在诊断时年轻与CRT之间存在统计学上的显着相互作用，表明在接受CRT的患者中，诊断时年轻与肥胖有关。这些发现可能有助于确定治疗后超重或肥胖风险增加的小儿ALL患者。

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