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首页> 外文期刊>Journal of pediatric hematology/oncology: Official journal of the American Society of Pediatric Hematology/Oncology >Effect of recombinant human growth hormone (rhGH) on hemoglobin concentration in children with idiopathic growth hormone deficiency-related anemia
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Effect of recombinant human growth hormone (rhGH) on hemoglobin concentration in children with idiopathic growth hormone deficiency-related anemia

机译：重组人生长激素（rhGH）对特发性生长激素缺乏症相关性贫血患儿血红蛋白浓度的影响

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摘要

Normocytic-normochromic anemia (NC/NC) has been attributed to impaired bone marrow erythropoiesis in growth hormone (GH)-deficient patients. Moreover, the GH/insulin-like growth factor-1 (IGF-1) axis has been implicated in erythropoiesis regulation. In this retrospective multicenter study, we evaluated the incidence of NC/NC anemia in 279 children (196 boys), median age 10.52 years, with isolated idiopathic GH deficiency, and the effect of recombinant human growth hormone (rhGH) therapy on hemoglobin levels. At 6-month intervals, we recorded the Hb standard deviation score (Hb-SDS), the IGF-1-SDS, weight, height, and pubertal stage. Forty-one boys and 7 girls had NC/NC anemia before starting substitutive therapy (-2.59 SD). The Hb-SDS was significantly increased (P<0.05) after 12 months of rhGH therapy. The effect of rhGH continued up to 48 months (-0.39 SD), at which point all children had normal hemoglobin values. In conclusion, rhGH therapy resulted in normal hemoglobin values in all children enrolled in the study. These data support the concept that the GH/IGF-1 axis promotes erythropoiesis in vivo.
机译：正常性-正常性贫血（NC / NC）归因于生长激素（GH）缺乏症患者的骨髓红细胞生成受损。此外，GH /胰岛素样生长因子-1（IGF-1）轴已参与红细胞生成调节。在这项回顾性多中心研究中，我们评估了279名儿童（196名男孩），中位年龄10.52岁，孤立性特发性GH缺乏以及重组人生长激素（rhGH）治疗对血红蛋白水平的影响，其NC / NC贫血的发生率。每隔6个月记录一次Hb标准差评分（Hb-SDS），IGF-1-SDS，体重，身高和青春期。开始替代治疗前，有41名男孩和7名女孩患有NC / NC贫血（-2.59 SD）。 rhGH治疗12个月后，Hb-SDS显着升高（P <0.05）。 rhGH的作用持续长达48个月（-0.39 SD），此时所有儿童的血红蛋白值均正常。总之，rhGH治疗可使所有参与研究的儿童的血红蛋白值均正常。这些数据支持GH / IGF-1轴在体内促进红细胞生成的概念。

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