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首页> 外文期刊>Clinics in dermatology >Severe cutaneous adverse drug reactions: who should treat, where and how?: Facts and controversies.
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Severe cutaneous adverse drug reactions: who should treat, where and how?: Facts and controversies.

机译：严重的皮肤不良药物反应：谁应该在哪里治疗以及如何治疗？：事实和争议。

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摘要

Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) are uncommon but extremely serious and often life-threatening mucocutaneous reactions characterized by extensive epithelial sloughing and systemic symptoms. There is no effective evidence-based treatment for severe cutaneous adverse reactions (SCAR) to drugs and no consensus on how to treat these patients. This contribution presents some of the controversies concerning the treatment of SCAR patients, including where and by whom, as well as the issue of the value of treatment with corticosteroids and intravenous immunoglobulin. Investigators agree that more studies are needed and that there are insufficient data to draw definite conclusions. The spectrum of disagreement is wide and the debate is ongoing. At the end, the important question is should we wait with our decisions until all these controversies are settled and we have more or full evidence. This question, as well as all others, is open for debate, evidently a "toxic" debate on toxic epidermal necrolysis.
机译：有毒的表皮坏死症（TEN）和史蒂文斯-约翰逊综合症（SJS）很少见，但极为严重，通常威胁生命的粘膜皮肤反应，其特征是广泛的上皮脱落和全身症状。没有针对药物的严重皮肤不良反应（SCAR）的有效循证治疗，也没有关于如何治疗这些患者的共识。这项贡献提出了一些与SCAR患者治疗有关的争议，包括在何处和由谁治疗，以及使用皮质类固醇和静脉注射免疫球蛋白的治疗价值问题。研究人员同意，需要进行更多的研究，并且没有足够的数据得出明确的结论。意见分歧的范围很广，辩论仍在进行中。最后，重要的问题是我们是否应该等待我们的决定，直到所有这些争议都得到解决，并且我们有了更多或充分的证据。这个问题以及所有其他问题都需要辩论，显然是关于毒性表皮坏死溶解的“毒性”辩论。

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