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首页> 外文期刊>Clinics in dermatology >Immunology of cutaneous lupus erythematosus.
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Immunology of cutaneous lupus erythematosus.

机译：皮肤红斑狼疮的免疫学。

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The cause and effect between ultraviolet light and cutaneous lupus erythematosus (CLE) is clear. In LE patients indeed, photosensitivity is one of the major diagnostic criteria of the systemic form of lupus erythematosus. This strong clinical association has led to the postulate that abnormal photosensitivity participates in the pathogenesis of cutaneous lesions in LE. What is not clear is how the ultraviolet radiation (UVR) induces cutaneous lesions in susceptible individuals despite the fact that profound effects of UVR on the cellular components of the skin have been extensively studied. The whole scenario is complicated by the relationship between sunlight and the cutaneous immune system. Pronounced effects of UVR on the cutaneous immune response further complicate the understanding of photosensitivity in LE. In addition, the network of cutaneous cytokines, chemokines, and adhesion molecules has become increasingly intricate, thus contributing to the genetic substrate of each individual, and to thetremendous complexity of the pathogenesis of CLE.
机译：紫外线与皮肤红斑狼疮（CLE）之间的因果关系很明确。实际上，在LE患者中，光敏性是系统性红斑狼疮的主要诊断标准之一。这种强烈的临床联系导致人们推测异常的光敏性参与了LE皮肤病变的发病机制。尚不清楚的是，尽管已经广泛研究了UVR对皮肤细胞成分的深远影响，但紫外线（UVR）如何在易感人群中引起皮肤损伤。阳光和皮肤免疫系统之间的关系使整个情况变得复杂。 UVR对皮肤免疫反应的明显作用进一步使对LE中的光敏性的理解更加复杂。另外，皮肤细胞因子，趋化因子和粘附分子的网络变得越来越复杂，从而促进了每个个体的遗传底物，并极大地增加了CLE的发病机理。

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