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首页> 外文期刊>Journal of Pharmaceutical and Biomedical Analysis: An International Journal on All Drug-Related Topics in Pharmaceutical, Biomedical and Clinical Analysis >Determination of ambroxol hydrochloride, methylparaben and benzoic acid in pharmaceutical preparations based on sequential injection technique coupled with monolithic column.
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Determination of ambroxol hydrochloride, methylparaben and benzoic acid in pharmaceutical preparations based on sequential injection technique coupled with monolithic column.

机译：序贯进样技术结合整体色谱柱测定药物制剂中盐酸氨溴索，对羟基苯甲酸甲酯和苯甲酸

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摘要

The porous monolithic columns show high performance at relatively low pressure. The coupling of short monoliths with sequential injection technique (SIA) results in a new approach to implementation of separation step to non-separation low-pressure method. In this contribution, a new separation method for simultaneous determination of ambroxol, methylparaben and benzoic acid was developed based on a novel reversed-phase sequential injection chromatography (SIC) technique with UV detection. A Chromolith SpeedROD RP-18e, 50-4.6 mm column with 10 mm precolumn and a FIAlab 3000 system with a six-port selection valve and 5 ml syringe were used for sequential injection chromatographic separations in our study. The mobile phase used was acetonitrile-tetrahydrofuran-0.05M acetic acid (10:10:90, v/v/v), pH 3.75 adjusted with triethylamine, flow rate 0.48 mlmin(-1), UV-detection was at 245 nm. The analysis time was <11 min. A new SIC method was validated and compared with HPLC. The method was found to be useful for the routine analysis of the active compounds ambroxol and preservatives (methylparaben or benzoic acid) in various pharmaceutical syrups and drops.
机译：多孔整体柱在相对较低的压力下显示出高性能。短整料与顺序注入技术（SIA）的结合产生了一种将分离步骤实施为非分离低压方法的新方法。在这一贡献中，基于具有紫外检测功能的新型反相顺序进样色谱（SIC）技术，开发了一种同时测定氨溴索，对羟基苯甲酸甲酯和苯甲酸的新分离方法。在我们的研究中，使用Chromolith SpeedROD RP-18e，具有10 mm预柱的50-4.6 mm色谱柱和带有六通选择阀和5 ml注射器的FIAlab 3000系统进行了连续进样色谱分离。所用的流动相为乙腈-四氢呋喃-0.05M乙酸（10：10：90，v / v / v），用三乙胺调节的pH 3.75，流速0.48 mlmin（-1），UV检测在245 nm。分析时间小于11分钟。验证了一种新的SIC方法并与HPLC进行了比较。发现该方法可用于常规分析各种药物糖浆和滴剂中的活性化合物氨溴索和防腐剂（对羟基苯甲酸甲酯或苯甲酸）。

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