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首页> 外文期刊>Journal of Pharmaceutical and Biomedical Analysis: An International Journal on All Drug-Related Topics in Pharmaceutical, Biomedical and Clinical Analysis >Characterization of metabolic profile of mosapride citrate in rat and identification of two new metabolites: Mosapride N-oxide and morpholine ring-opened mosapride by UPLC-ESI-MS/MS.
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Characterization of metabolic profile of mosapride citrate in rat and identification of two new metabolites: Mosapride N-oxide and morpholine ring-opened mosapride by UPLC-ESI-MS/MS.

机译：用UPLC-ESI-MS / MS鉴定柠檬酸莫沙必利在大鼠中的代谢谱并鉴定两种新的代谢物：莫沙必利N-氧化物和吗啉开环莫沙必利。

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摘要

The identification and structure elucidation of metabolites of mosapride, a selective gastroprokinetic agent, was investigated in rats. After oral administration, samples of rat urine, bile, feces and plasma were collected and analyzed by a selective UPLC-ESI-MS/MS method. Altogether 18 metabolites were detected and at least 15 metabolites were reported in rat for the first time. Two new metabolites, mosapride N-oxide in rat bile, urine and plasma, morpholine ring-opened mosapride in plasma and feces, were identified by comparison with the reference standards. One known major mammalian metabolite, des-p-fluorobenzyl mosapride, was also identified. The molecular structures of nine phase I metabolites and six phase II metabolites of mosapride were elucidated based on the characteristics of their protonated molecular ions, product ions and chromatographic retention times. The phase I metabolites were mainly transformed by four main metabolism pathways, dealkylation, N-oxidation, morpholine ring cleavage and hydroxylation, with dealkylation as the predominant metabolic pathway, while phase II metabolites were mainly formed by glucuronidation. The relatively comprehensive metabolic pathway of mosapride was proposed.
机译：在大鼠中研究了莫沙必利（一种选择性胃肠动力药）的代谢产物的鉴定和结构解析。口服后，收集大鼠尿液，胆汁，粪便和血浆样品，并通过选择性UPLC-ESI-MS / MS方法进行分析。在大鼠中总共检测到18种代谢物，并且首次报道了至少15种代谢物。通过与参考标准进行比较，鉴定了两种新的代谢物：大鼠胆汁，尿液和血浆中的莫沙必利N-氧化物，血浆和粪便中的吗啉开环莫沙必利。还鉴定了一种已知的主要哺乳动物代谢产物，des-对氟苄基莫沙必利。根据质子化分子离子，产物离子和色谱保留时间的特点，阐明了莫沙必利的九种I相代谢物和6种II型代谢物的分子结构。 I相代谢物主要通过四个主要代谢途径转化，即脱烷基化，N-氧化，吗啉环裂解和羟基化，其中脱烷基化为主要代谢途径，而II相代谢物主要通过葡糖醛酸形成。提出了相对全面的莫沙必利代谢途径。

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