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首页> 外文期刊>Clinics in dermatology >Autoimmune blistering diseases in the elderly.
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Autoimmune blistering diseases in the elderly.

机译：老年人自身免疫性水疱病。

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摘要

Autoimmune blistering diseases are a significant cause of morbidity and mortality in the elderly population. Given the advancing age of the population, the incidence of these disorders, particularly bullous pemphigoid, is expected to rise. This contribution reviews autoimmune immunobullous disorders of particular relevance in the elderly population. These include bullous pemphigoid, cicatricial pemphigoid, epidermolysis bullosa acquisita, pemphigus, paraneoplastic pemphigus, and linear immunoglobulin A bullous dermatosis. Because therapy and management of individual immunobullous dermatoses differ, establishing the diagnosis is often critically important. An overall approach to bullous diseases in the elderly, as well as key clinical features, appropriate diagnostic tests, microscopic findings, immunofluorescence microscopy patterns, and molecular targets for select disorders are reviewed. Elucidation of antigenic targets at the molecular level has allowed for development of serum enzyme-linked immunofluorescence assays, which have enhanced diagnostic accuracy for several autoimmune blistering disorders. Given the relative rarity of these diseases, large randomized trials evaluating efficacy of various treatments are few, and therapy for most immunobullous disorders in the elderly has not been standardized. Despite this, appropriate therapeutic considerations for each condition are presented and the evidence for them is reviewed.
机译：自身免疫性水疱病是老年人口发病和死亡的重要原因。随着人口年龄的增长，预计这些疾病，特别是大疱性类天疱疮的发病率将上升。这一贡献回顾了老年人群中特别相关的自身免疫性免疫球疾病。这些包括大疱性天疱疮，瘢痕性天疱疮，表皮松解性大疱性天疱疮，天疱疮，副肿瘤性天疱疮和线性免疫球蛋白A大疱性皮肤病。由于个别免疫性鳞状上皮性皮肤病的治疗和管理方法不同，因此建立诊断通常至关重要。审查了老年人大疱性疾病的总体方法，以及关键的临床特征，适当的诊断测试，显微镜检查结果，免疫荧光显微镜检查方法和针对特定疾病的分子靶标。在分子水平上的抗原靶标的阐明允许开发血清酶联免疫荧光测定法，其对几种自身免疫性水疱性疾病具有增强的诊断准确性。考虑到这些疾病的相对稀少性，很少有评估各种治疗方法疗效的大型随机试验，而且针对大多数老年人免疫球疾病的治疗方法尚未标准化。尽管如此，仍针对每种情况提出了适当的治疗考虑，并对其证据进行了审查。

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