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Cystic fibrosis-related diabetes

机译：囊性纤维化相关糖尿病

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Cystic fibrosis (CF) is the most common life-threatening autosomal recessive genetic disease in the United States with an incidence of 1 in 3,500 live births. According to the Cystic Fibrosis Foundation's (CFF) patient registry, approximately 30,000 children and adults in the United States are affected. In the 1950s, a diagnosis of CF resulted in a life expectancy of only 15 years; however, with advances in medical and nutritional management, life expectancy has improved significantly. The CFF now reports a life expectancy of 37.4 years. In addition, more than 45% of patients living with CF are older than 18 years. Improved life expectancy is a positive outcome, although it has led to a need to address previously overlooked complications and comorbities. Infertility, bone disease, depression, glucose intolerance, and CF-related diabetes (CFRD) have all become integral pieces to successful management of the aging CF population (CFF, 2009).
机译：囊性纤维化（CF）是美国最常见的威胁生命的常染色体隐性遗传疾病，每3,500例活产中就有1例发生。根据囊性纤维化基金会（CFF）的患者注册表，美国约有30,000儿童和成人受到影响。在1950年代，对CF的诊断导致预期寿命只有15年。但是，随着医学和营养管理的进步，预期寿命已大大提高。现在，CFF的预期寿命为37.4岁。此外，超过45％的CF患者年龄超过18岁。预期寿命的改善是一个积极的成果，尽管它导致需要解决以前被忽视的并发症和并发症。不育症，骨病，抑郁症，葡萄糖耐受不良和与CF相关的糖尿病（CFRD）都已成为成功管理衰老CF人群的重要组成部分（CFF，2009）。

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