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首页> 外文期刊>Diabetes care >Comparison of cystic fibrosis-related diabetes with type 1 diabetes based on a German/Austrian pediatric diabetes registry
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Comparison of cystic fibrosis-related diabetes with type 1 diabetes based on a German/Austrian pediatric diabetes registry

机译：根据德国/奥地利儿科糖尿病登记表比较囊性纤维化相关糖尿病与1型糖尿病

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OBJECTIVE-The prevalence of cystic fibrosis-related diabetes (CFRD) has increased with improved life expectancy of patients. Clinical and care characteristics were compared with type 1 diabetes mellitus (T1DM) in a multicenter analysis of pediatric data. RESEARCH DESIGN AND METHODS-Auxological and treatment data from 47,227 patients aged younger than 21 years with CFRD or T1DM in the German/Austrian Diabetes Prospective Documentation Initiative registry were analyzed by multivariable mixed regression modeling. RESULTS-Diabetes onset (mean [interquartile range]) occurred later in individuals with CFRD (14.5 [11.8-16.3] years) than in individuals with T1DM (8.5 [4.9-11.8] years), with female preponderance in CFRD (59.1% vs. 47.5%; P < 0.01). CFRD patients had lower BMI standard deviation scores (20.85 [21.59 to 20.12] vs. +0.52 [20.10 to +1.16]; P < 0.01) and lower HbA1c (6.87% vs. 7.97%; P < 0.01). Self-monitoring of blood glucose was more frequent in patients with T1DM(4.5 vs. 3.5; P<0.01); 72%of CFRD patients received insulin. In insulintreated patients, insulin dosage adjusted for age, sex, and diabetes duration differed significantly (T1DM: 0.79 IE per kilogram of body weight; CFRD: 0.83 IE per kilogram of body weight). Use of short-acting and long-acting insulin analogs was significantlymore frequent in T1DM(47%vs. 39% and 37% vs. 28%; both P < 0.05). Metabolic control in CFRD patients without insulin was better compared with CFRD on insulin (HbA1c: 6.00 vs. 7.12; P <0.01), but duration of disease was significantly shorter (0.8 years [0.1-2.4] compared with 2.4 years [0.6-4.6]). There was no significant difference for BMI standard deviations scores between CFRD patients with or without insulin treatment. CONCLUSIONS-Pediatric patients with CFRD show clear auxological and metabolic differences from those with T1DM, with different treatment choices. ? 2013 by the American Diabetes Association.
机译：目的-囊性纤维化相关糖尿病（CFRD）的患病率随着患者预期寿命的提高而增加。在多中心儿科数据分析中，将临床和护理特征与1型糖尿病（T1DM）进行了比较。研究设计和方法-通过多变量混合回归模型分析了来自德国/奥地利糖尿病前瞻性文献倡议登记处的47,227名年龄小于21岁的CFRD或T1DM患者的治疗和治疗数据。结果CFRD患者（14.5 [11.8-16.3]岁）的糖尿病发病（平均[四分位数间距]）晚于T1DM患者（8.5 [4.9-11.8]岁）的糖尿病发作，女性以CFRD占优势（59.1％vs 47.5％; P <0.01）。 CFRD患者的BMI标准差评分较低（20.85 [21.59至20.12]与+0.52 [20.10至+1.16]; P <0.01）和HbA1c较低（6.87％与7.97％; P <0.01）。 T1DM患者的血糖自我监测更为频繁（4.5 vs. 3.5; P <0.01）; CFRD患者中有72％接受了胰岛素治疗。在接受胰岛素治疗的患者中，针对年龄，性别和糖尿病持续时间进行调整的胰岛素剂量存在显着差异（T1DM：每千克体重0.79 IE; CFRD：每千克体重0.83 IE）。在T1DM中使用短效和长效胰岛素类似物的频率明显更高（47％vs. 39％和37％vs. 28％;两者均P <0.05）。没有胰岛素的CFRD患者的代谢控制优于胰岛素的CFRD（HbA1c：6.00 vs. 7.12; P <0.01），但病程明显缩短（0.8年[0.1-2.4]，而2.4年[0.6-4.6] ]）。接受或不接受胰岛素治疗的CFRD患者之间的BMI标准差评分无显着差异。结论：CFRD患儿与T1DM患儿相比，在治疗和选择上有明显的区别。 ？ 2013年由美国糖尿病协会颁发。

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