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首页> 外文期刊>Biophysical Chemistry: An International Journal Devoted to the Physical Chemistry of Biological Phenomena >ENERGY, CONTROL AND DNA STRUCTURE IN THE LIVING CELL
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ENERGY, CONTROL AND DNA STRUCTURE IN THE LIVING CELL

机译：生命细胞中的能量，控制和DNA结构

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Maintenance (let alone growth) of the highly ordered living cell is only possible through the continuous input of free energy. Coupling of energetically downhill processes (such as catabolic reactions) to uphill processes is essential to provide this free energy and is catalyzed by enzymes either directly or via ''storage'' in an intermediate high energy form, i.e., high ATP/ADP ratio or H+ ion gradient. Although maintenance of a sufficiently high ATP/ADP ratio is essential to overcome the thermodynamic burden of uphill processes, it is not clear to what degree enzymes that control this ratio also control cell physiology. Indeed, in the living cell homeostatic control mechanisms might exist for the free-energy transduction pathways so as to prevent perturbation of cellular function when the Gibbs energy supply is compromised. This presentation addresses the extent to which the intracellular ATP level is involved in the control of cell physiology, how the elaborate control of cell function may be analyzed theoretically and quantitatively, and if this can be utilized selectively to affect certain cell types. [References: 118]
机译：只有通过连续输入自由能，才能维持（高度增长的）有序活细胞。能量旺盛的下坡过程（例如分解代谢反应）与上坡过程的耦合对于提供这种自由能至关重要，并且直接或通过“存储”酶以中间高能形式（即高ATP / ADP比或H +离子梯度。尽管维持足够高的ATP / ADP比例对于克服上坡过程的热力学负担至关重要，但尚不清楚控制该比例的酶在多大程度上也能控制细胞生理。实际上，在活细胞中，可能存在自由能传导途径的稳态控制机制，以防止在吉布斯能量供应受到损害时细胞功能的扰动。本演讲介绍了细胞内ATP水平参与细胞生理控制的程度，如何从理论和定量上分析精细的细胞功能控制，以及是否可以有选择地利用它来影响某些细胞类型。 [参考：118]

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