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首页> 外文期刊>Journal of pharmaceutical sciences. >Microemulsions for dermal drug delivery studied by dynamic light scattering: Effect of interparticle interactions in oil-in-water microemulsions.
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Microemulsions for dermal drug delivery studied by dynamic light scattering: Effect of interparticle interactions in oil-in-water microemulsions.

机译：通过动态光散射研究用于皮肤药物递送的微乳剂：水包油微乳剂中颗粒间相互作用的影响。

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摘要

Dynamic light scattering (DLS) was used to study the droplet size and the droplet interaction of o/w microemulsions (MEs) consisting of oils, a blend of a high and a low hydrophilic-lipophilic balance (HLB) surfactant, and a hydrophilic phase (propylene glycol/water). Like many MEs, these systems could not be diluted to infinite dilution without phase separation. Consequently, to allow a meaningful calculation of droplet diameter from data obtained from DLS, it is necessary to correct scattering measurements in high concentration regions for the nonideality arising from interparticle interaction. Scattering data were corrected for interparticle interaction using a suitable interaction model proposed for our systems. From the total interparticle interaction energy, coagulation time was calculated. The ratio between rapid and slow coagulation was of the order of 10(100), which is consistent with the observed stability of the MEs studied.
机译：动态光散射（DLS）用于研究o / w微乳液（MEs）的液滴尺寸和液滴相互作用，该微乳液由油，高和低亲水-亲脂平衡（HLB）表面活性剂的混合物以及亲水相组成（丙二醇/水）。与许多ME一样，如果不进行相分离，则无法将这些系统稀释至无限稀释。因此，为了允许根据从DLS获得的数据有意义地计算液滴直径，有必要针对由于粒子间相互作用而引起的非理想性，对高浓度区域中的散射测量进行校正。使用为我们的系统建议的合适的相互作用模型，对散射数据进行了粒子间相互作用的校正。从总的颗粒间相互作用能计算凝结时间。快速凝结和慢速凝结之间的比率约为10（100），这与所观察的ME的稳定性一致。

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