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首页> 外文期刊>Journal of pharmaceutical sciences. >An investigation into the interaction between taste masking fatty acid microspheres and alkaline buffer using thermal and spectroscopic analysis.
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An investigation into the interaction between taste masking fatty acid microspheres and alkaline buffer using thermal and spectroscopic analysis.

机译：使用热和光谱分析研究掩味脂肪酸微球与碱性缓冲液之间的相互作用。

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Fatty acid-based microspheres may be used for the controlled delivery and taste masking of therapeutic agents, although the mechanisms involved in the release process are poorly understood. In this investigation, microspheres composed of high purity stearic and palmitic acid were prepared using a spray-chilling protocol. In addition, samples of binary fatty acid systems, fatty acid salts and acid-soaps were prepared to allow comparison with the microspheres. The interaction with alkaline buffer, into which release is known to be rapid, was studied using DSC and powder XRD with a view to examining the physicochemical changes undergone by the microspheres as a result of exposure to this medium. New species were identified for the postimmersion microsphere systems; similarities between the thermal and spectroscopic properties of these materials and the acid-soap references indicated the formation of acid-soaps during the exposure to the medium. The data indicate that simple exposure to buffer may result in the formation of acid soaps. This in turn has implications for understanding not only the release of drugs from the microspheres but also the biological fate of fatty acids on ingestion.
机译：基于脂肪酸的微球可用于治疗剂的受控递送和掩味，尽管对释放过程中涉及的机理知之甚少。在这项研究中，使用喷雾冷却方案制备了由高纯度硬脂酸和棕榈酸组成的微球。此外，还准备了二元脂肪酸体系，脂肪酸盐和酸皂的样品，以便与微球进行比较。使用DSC和粉末XRD研究了与碱性缓冲液之间的相互作用，已知该缓冲液的释放迅速，以检查微球由于暴露于该介质而发生的物理化学变化。确定了浸没后微球系统的新物种;这些材料的热性质和光谱性质与酸皂参考文献之间的相似之处表明，在暴露于介质期间会形成酸皂。数据表明，简单地暴露于缓冲液中可能导致形成酸皂。反过来，这不仅对理解药物从微球的释放，而且对于摄入脂肪酸的生物学命运具有重要意义。

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