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首页> 外文期刊>Journal of pharmaceutical sciences. >Investigation of solid-state NMR line widths of ibuprofen in drug formulations.
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Investigation of solid-state NMR line widths of ibuprofen in drug formulations.

机译：布洛芬在药物制剂中的固态NMR线宽研究。

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摘要

Solid-state nuclear magnetic resonance spectroscopy (SSNMR) line widths were measured for various ibuprofen preparations, including crystallization from different solvents (acetone, acetonitrile, methanol), melt-quenching, manual grinding, cryogrinding, compacting, and by blending with various excipients. Ibuprofen recrystallized from acetonitrile exhibited broader lines than ibuprofen recrystallized from either acetone or methanol. Manually ground ibuprofen had SSNMR line widths that were indistinguishable from the commercial sample, but cryoground ibuprofen had larger line widths than either. Physical mixtures with most excipients decreased the SSNMR line widths. Only dilution in talc led to line width increases, which is attributed to the magnetic susceptibility anisotropy of the talc excipient. Our results show that SSNMR line widths can be used to understand physical characteristics including particle size and morphology, degree of order in the materials, and physical environment. (c) 2006 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 95: 1586-1594, 2006.
机译：测量了各种布洛芬制剂的固态核磁共振波谱（SSNMR）线宽，包括从不同溶剂（丙酮，乙腈，甲醇）中的结晶，熔融淬火，手动研磨，冷冻粉碎，压实以及与各种赋形剂共混。从乙腈中重结晶的布洛芬比从丙酮或甲醇中重结晶的布洛芬具有更宽的谱线。手动研磨的布洛芬的SSNMR线宽与市售样品无法区分，但冷冻研磨的布洛芬的线宽比任何一种都大。与大多数赋形剂的物理混合物降低了SSNMR线宽。仅在滑石中稀释导致线宽增加，这归因于滑石赋形剂的磁化率各向异性。我们的结果表明，SSNMR线宽可用于理解物理特性，包括粒径和形态，材料的有序度以及物理环境。 （c）2006 Wiley-Liss，Inc.和美国药剂师协会J Pharm Sci 95：1586-1594，2006。

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