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首页> 外文期刊>Journal of pharmaceutical sciences. >Solubilization and dissolution of tamoxifen-hydroxybutenyl cyclodextrin complexes.
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Solubilization and dissolution of tamoxifen-hydroxybutenyl cyclodextrin complexes.

机译：他莫昔芬-羟基丁烯基环糊精复合物的溶解和溶解。

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摘要

The solubility and dissolution of tamoxifen base and tamoxifen citrate with and without hydroxybutenyl-beta-cyclodextrin (HBenBCD) in aqueous and organic media were examined. The solubility of tamoxifen was greatly enhanced by complexation with HBenBCD; pH of the medium, and choice of buffer significantly impacted the amount of drug that could be solubilized. Different tamoxifen:HBenBCD formulations were prepared, including liquid fill capsule formulations, and their dissolution profiles were obtained. These dissolution studies demonstrated that enhanced solubilization of tamoxifen with HBenBCD was effective across a wide variety of formulation options. By complexation of tamoxifen base with HBenBCD, it was possible to obtain solubility and dissolution profiles for tamoxifen base that were essentially identical to that of tamoxifen citrate. Association
机译：检查了他莫昔芬碱和他莫昔芬柠檬酸盐在有或没有羟基丁烯基-β-环糊精（HBenBCD）的情况下在水性介质和有机介质中的溶解度和溶解度。他莫昔芬与HBenBCD的结合大大提高了其溶解度。培养基的pH值和缓冲液的选择会显着影响可溶解药物的量。制备了不同的他莫昔芬：HBenBCD制剂，包括液体填充胶囊制剂，并获得了它们的溶出曲线。这些溶出度研究表明，他莫昔芬与HBenBCD的增溶作用在多种制剂选择中均有效。通过他莫昔芬碱与HBenBCD的络合，可以获得他莫昔芬碱的溶解度和溶出度，其与柠檬酸他莫昔芬的溶解度和溶出度基本相同。协会

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