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首页> 外文期刊>Journal of pharmaceutical sciences. >The use of colloid probe microscopy to predict aerosolization performance in dry powder inhalers: AFM and in vitro correlation.
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The use of colloid probe microscopy to predict aerosolization performance in dry powder inhalers: AFM and in vitro correlation.

机译：使用胶体探针显微镜预测干粉吸入器的雾化性能：AFM和体外相关性。

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摘要

The atomic force microscope (AFM) colloid probe technique was utilized to measure cohesion forces (separation energy) between three drug systems as a function of relative humidity (RH). The subsequent data was correlated with in vitro aerosolization data collected over the same RH range. Three drug-only systems were chosen for study; salbutamol sulphate (SS), triamcinolone acetonide (TAA), and di-sodium cromoglycate (DSCG). Analysis of the AFM and in vitro data suggested good correlations, with the separation energy being related inversely to the aerosolization performance (measured as fine particle fraction, FPF(LD)). In addition, the relationship between, cohesion, RH, and aerosolization performance was drug specific. For example, an increase in RH between 15% and 75% resulted in increased cohesion and decreased FPF(LD) for SS and DSCG. In comparison, for TAA, a decrease in cohesion and increased FPF(LD) was observed when RH was increased (15-75%). Linear regression analysis comparing AFM with in vitro data indicated R(2) values > 0.80, for all data sets, suggesting the AFM could be used to indicate in vitro aerosolization performance.
机译：原子力显微镜（AFM）胶体探针技术用于测量三种药物系统之间的内聚力（分离能），该内聚力是相对湿度（RH）的函数。随后的数据与在相同RH范围内收集的体外雾化数据相关。选择了三种仅药物系统进行研究;硫酸沙丁胺醇（SS），曲安奈德（TAA）和色甘酸二钠（DSCG）。原子力显微镜和体外数据的分析显示出良好的相关性，分离能量与雾化性能成反比（以细小颗粒分数，FPF（LD）衡量）。另外，内聚力，相对湿度和雾化性能之间的关系是药物特异性的。例如，相对湿度在15％到75％之间的增加导致SS和DSCG的内聚力增加，FPF（LD）降低。相比之下，对于TAA，当RH增加（15-75％）时，内聚力降低，FPF（LD）升高。对于所有数据集，将AFM与体外数据进行比较的线性回归分析表明R（2）值> 0.80，这表明AFM可用于指示体外雾化性能。

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