Molecular aspects of phytoestrogen selective binding at estrogen receptors.

Turner JV; Agatonovic-Kustrin S; Glass BD

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Molecular aspects of phytoestrogen selective binding at estrogen receptors.

机译：植物雌激素在雌激素受体上选择性结合的分子方面。

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Phytoestrogens are a diverse group of plant-derived compounds that structurally or functionally mimic mammalian estrogens and show potential benefits for human health. An increase in phytoestrogen research over the past few decades has demonstrated the biological complexity of phytoestrogens, which belong to several different chemical classes and act through diverse mechanisms. Identification of the estrogen receptor beta (ERbeta) and research into various ligand classes has enabled elucidation of molecular aspects important in selective ER binding. This article explores the structural characteristics and significance of functional groups as they relate to phytoestrogen selectivity for ER binding.

机译：植物雌激素是多种植物来源的化合物，它们在结构或功能上模仿哺乳动物的雌激素，并显示出对人类健康的潜在益处。在过去的几十年中，植物雌激素研究的增加证明了植物雌激素的生物学复杂性，植物雌激素属于几种不同的化学类别，并通过多种机制起作用。雌激素受体β（ERbeta）的鉴定和对各种配体类别的研究已使阐明选择性ER结合中重要的分子方面成为可能。本文探讨了功能基团的结构特征和意义，因为它们与植物雌激素对内质网结合的选择性有关。

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《Journal of pharmaceutical sciences.》 |2007年第8期|共7页
作者
Turner JV; Agatonovic-Kustrin S; Glass BD;
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正文语种 eng
中图分类药学;
关键词
phyto-estrogen; binding; Estrogen Receptors; estrogen receptor beta;

机译：植物雌激素;结合;雌激素受体;雌激素受体β;

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1. Molecular aspects of phytoestrogen selective binding at estrogen receptors. [J] . Turner JV, Agatonovic-Kustrin S, Glass BD Journal of pharmaceutical sciences. . 2007,第8期

机译：植物雌激素在雌激素受体上选择性结合的分子方面。
2. Structural features of diverse ligands influencing binding affinities to estrogen α and estrogen β receptors. Part II. Molecular descriptors calculated from conformation of the ligands in the complex resulting from previous docking study [J] . Morena Spreafico, Elena Boriani, Emilio Benfenati, Molecular diversity . 2007,第3a4期

机译：影响与雌激素α和雌激素β受体的结合亲和力的各种配体的结构特征。第二部分根据先前对接研究得出的复合物中配体构象计算的分子描述子
3. Structural features of diverse ligands influencing binding affinities to Estrogen α and Estrogen β receptors. Part I: molecular descriptors calculated from minimal energy conformation of isolated ligands [J] . Elena Boriani, Morena Spreafico, Emilio Benfenati, Molecular Diversity . 2007,第3a4期

机译：影响与雌激素α和雌激素β受体结合亲和力的各种配体的结构特征。第一部分：由孤立配体的最小能量构象计算的分子描述子
4. Molecular Dynamic Simulations Suggest that P152R Mutation Within MeCP2 Can Lead to Higher DNA Binding Affinity and Loss of Selective Binding to Methylated DNA [C] . Dino Franklin International Conference on Practical Applications of Computational Biology and Bioinformatics . 2019

机译：分子动态模拟表明，MECP2内的P152R突变可以导致更高的DNA结合亲和力和对甲基化DNA的选择性结合的丧失
5. 4-Ethoxymethylphenol: A novel phytoestrogen that acts as an agonist for human estrogen receptors. [D] . Pearce, Virginia. 2001

机译：4-乙氧基甲基苯酚：一种新型植物雌激素，可作为人类雌激素受体的激动剂。
6. Selective Estrogen Receptor Modulator and prostimulatory effects of phytoestrogen β-ecdysone in Tinospora cordifolia on osteoblast cells [O] . Ganesan Abiramasundari, C.M. Mohan Gowda, Meenakshisundaram Sreepriya 2018

机译：田鼠孢中选择性雌激素受体调节剂和植物雌激素β-蜕皮激素对成骨细胞的促进作用
7. A Select Combination of Clinically Relevant Phytoestrogens Enhances Estrogen Receptor β-Binding Selectivity and Neuroprotective Activities in Vitro and in Vivo [O] . Liqin Zhao, Zisu Mao, Roberta Diaz Brinton 2009

机译：临床相关的植物雌激素的选择组合增强了雌激素受体β-结合选择性和体外和体内神经保护活动
8. Molecular Mechanism of Action of Genistein and Related Phytoestrogens in Estrogen Receptor Dependent and Independent Growth of Breast Cancer Cells [R] . Thomas, T. 2000

机译：金雀异黄素及相关植物雌激素在雌激素受体依赖和独立生长的乳腺癌细胞中的作用分子机制

Molecular aspects of phytoestrogen selective binding at estrogen receptors.

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