• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of pharmaceutical sciences. >Single-droplet evaporation kinetics and particle formation in an acoustic levitator. Part 1: Evaporation of water microdroplets assessed using boundary-layer and acoustic levitation theories.
【24h】

Single-droplet evaporation kinetics and particle formation in an acoustic levitator. Part 1: Evaporation of water microdroplets assessed using boundary-layer and acoustic levitation theories.

机译：声悬浮器中的单液滴蒸发动力学和颗粒形成。第1部分：使用边界层和声悬浮理论评估的水微滴蒸发。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The suitability of a single droplet drying acoustic levitator as a model for the spray drying of aqueous, pharmaceutically-relevant solutes used to produce protein-loaded particles has been examined. The acoustic levitator was initially evaluated by measuring the drying rates of droplets of pure water in dependence of drying-air temperature and flow rate. The measured drying rates were higher than those predicted by boundary layer theory because of the effects of primary acoustic streaming. Sherwood numbers of 2.6, 3.6, and 4.4 at drying-air temperatures of 25 degrees C, 40 degrees C, and 60 degrees C were determined, respectively. Acoustic levitation theory could predict the measured drying rates and Sherwood numbers only when a forced-convection drying-air stream was used to neuralize the retarding effect of secondary acoustic streaming on evaporation rate. At still higher drying-air flow rates, the Ranz-Marshall correlation accurately predicts Sherwood number, provided a stable droplet position in the standing acoustic wave is maintained. The measured Sherwood numbers and droplet Reynolds numbers show that experiments performed in the levitator in still air are taking place effectively under conditions of substantial forced convection. The similitude of these values to those occurring in spray dryers is fortuitous for the suitability of the acoustic levitator as a droplet evaporation model for spray drying. (c) 2007 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 96: 2274-2283, 2007.
机译：已经检查了单个液滴干燥声悬浮器作为用于喷雾干燥用于生产载有蛋白质的颗粒的药学上相关的溶质的模型的适用性。首先根据干燥空气温度和流速通过测量纯净水液滴的干燥速率来评估声悬浮器。由于主要声流的影响，测得的干燥速率高于边界层理论预测的干燥速率。在干燥空气温度分别为25摄氏度，40摄氏度和60摄氏度下，舍伍德数分别为2.6、3.6和4.4。仅当使用强制对流干燥空气流来神经化次生声流对蒸发速率的阻滞作用时，声悬浮理论才能预测测得的干燥速率和舍伍德数。在更高的干燥空气流速下，只要保持驻声波中的液滴位置稳定，Ranz-Marshall相关性就能准确预测舍伍德数。测得的舍伍德数和雷诺液滴数表明，在静止空气中在悬浮机中进行的实验是在强对流条件下有效进行的。这些值与在喷雾干燥器中出现的值相似，这是因为声悬浮剂适合作为喷雾干燥的液滴蒸发模型。 （c）2007 Wiley-Liss，Inc.和美国药剂师协会J Pharm Sci 96：2274-2283，2007。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号