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首页> 外文期刊>Journal of pharmaceutical sciences. >Comparative characterization of the physicochemical behavior and skin permeation of extruded DPPC liposomes modified by selected additives.
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Comparative characterization of the physicochemical behavior and skin permeation of extruded DPPC liposomes modified by selected additives.

机译：经选定添加剂改性的DPPC脂质体的理化行为和皮肤渗透性的比较表征。

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摘要

The purpose of the present study was to analyze the influence of cholesterol (CHOL), stearylamine (SA), dicetyl phosphate (DCP), and xylenesulfonic acid sodium salt (SXS) in extruded DPPC (1,2-dipalmitoyl-sn-glycero-3-phosphocholine) liposomes on their size, shape, and skin permeation of the model drug progesterone. The additives were incorporated in different molar ratios in relation to the phospholipid content. It could be proven that different molar ratios of the additives to lipids were able to modify liposome size, zeta potential, and the characteristic phase transition temperature of the lipids. In standard skin diffusion experiments SA and SXS increased the progesterone permeation two- to fourfold respectively after 48 h compared to the control.
机译：本研究的目的是分析胆固醇（CHOL），硬脂胺（SA），磷酸二鲸蜡酯（DCP）和二甲苯磺酸钠盐（SXS）在挤出的DPPC（1,2-二棕榈酰-sn-甘油- 3-磷酸​​胆碱脂质体在模型药物黄体酮的大小，形状和皮肤渗透性上的作用。相对于磷脂含量以不同摩尔比掺入添加剂。可以证明，添加剂与脂质的不同摩尔比能够改变脂质体的大小，ζ电势和脂质的特征相变温度。在标准的皮肤扩散实验中，与对照组相比，SA和SXS在48小时后将孕酮的渗透率分别提高了2到4倍。

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