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首页> 外文期刊>Journal of pharmaceutical sciences. >Effect of placental fatty acid metabolism and regulation by peroxisome proliferator activated receptor on pregnancy and fetal outcomes.
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Effect of placental fatty acid metabolism and regulation by peroxisome proliferator activated receptor on pregnancy and fetal outcomes.

机译：胎盘脂肪酸代谢和过氧化物酶体增殖物激活受体的调节对妊娠和胎儿结局的影响。

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摘要

Fatty acids, particularly the omega-3 and omega-6 essential fatty acids (EFAs), are considered critical nutritional sources for the developing fetus. The placenta governs the fetal supply of fatty acids via two processes: transport and metabolism. Placental fatty acid metabolism can play a critical role in guiding pregnancy and fetal outcome. EFAs can be metabolized to important cell signaling molecules in placenta by several major isoform families including: the Cytochrome P450 subfamily 4A (CYP4A); Cyclooxygenases (COXs); and Lipoxygenases (LOXs). Peroxisome proliferator-activated nuclear receptors (PPARs) have been demonstrated to regulate a number of placental fatty acid/lipid homeostasis-related proteins (e.g., metabolizing enzymes and transporters). The present review summarizes research on the molecular and functional relevance of fatty acid metabolizing enzymes and the role of PPARs in regulating their expression in the mammalian placenta. Elucidating the pathways of placental fatty acid metabolism and the regulatory processes governing these pathways is critical for advancing our understanding of the role of placenta in supplying EFAs to the developing fetus and the potential implications on pregnancy and fetal outcome. A more complete understanding of placental fatty acid disposition may also provide a basis for nutritional/pharmacological interventions to ameliorate the risk of adverse pregnancy and/or fetal outcomes.
机译：脂肪酸，特别是omega-3和omega-6必需脂肪酸（EFA），被认为是发育中胎儿的关键营养来源。胎盘通过两个过程控制胎儿的脂肪酸供应：运输和代谢。胎盘脂肪酸代谢可在指导妊娠和胎儿结局中起关键作用。 EFA可以通过几种主要的同工型家族代谢为胎盘中的重要细胞信号分子，包括：细胞色素P450亚家族4A（CYP4A）;环氧合酶（COX）;和脂氧合酶（LOXs）。已证明过氧化物酶体增殖物激活的核受体（PPAR）调节许多胎盘脂肪酸/脂质体内稳态相关蛋白（例如，代谢酶和转运蛋白）。本综述总结了脂肪酸代谢酶的分子和功能相关性以及PPAR在调节其在哺乳动物胎盘中的表达中的作用的研究。阐明胎盘脂肪酸代谢的途径以及控制这些途径的调控过程，对于增进我们对胎盘在向发育中的胎儿提供全民教育中的作用以及对妊娠和胎儿结局的潜在影响的理解至关重要。对胎盘脂肪酸处置的更全面了解也可为营养/药理干预措施改善妊娠不良和/或胎儿结局的风险提供基础。

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